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Improved preparation method of notoginseng root capsules for dysmenorrhoea

A technology for capsules and dysmenorrhea, applied in the field of Chinese patent medicine preparation, can solve the problems of reduced bioavailability, impact on differences in capsule loading, and prolonged disintegration time.

Inactive Publication Date: 2016-10-19
惠州市九惠制药股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the product is prone to sticking and punching during the production process, and its fluidity is poor, which affects the difference in capsule loading; after a period of storage, the disintegration time will be prolonged and the bioavailability will decrease

Method used

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  • Improved preparation method of notoginseng root capsules for dysmenorrhoea
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  • Improved preparation method of notoginseng root capsules for dysmenorrhoea

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Embodiment 1

[0016] An improved preparation method of Tianqi Tongjing Capsules, the preparation steps are:

[0017] (1) Panax notoginseng is superfinely pulverized separately, Wulingzhi, Puhuang, Yanhusuo, Chuanxiong, woody, fennel, and borneol are pulverized into fine powder, and mixed for later use;

[0018] (2) The weight ratio of the powder obtained in step (1) and the filler is 1:0.5, after mixing, adding a wetting agent, and wet extrusion granulation; the filler is starch with a weight ratio of 7:1:1 , dextrin and lactose. The wetting agent is 70% by weight ethanol solution and 3% by weight povidone solution.

[0019] (3) The granules obtained in step (2) were dried in an oven at 60°C for about 60 minutes to obtain dried granules, which were sized and packed into capsules.

[0020] Under the guidance of traditional Chinese medicine theory, the present invention applies modern pharmaceutical technology to improve the preparation process of the preparation in order to improve the flu...

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Abstract

The invention relates to the field of a preparation method and technology of Chinese patent medicines. The invention provides an improved preparation method of notoginseng root capsules for dysmenorrhoea. The preparation method comprises the following steps: (1) individual ultra-fine pulverization is carried out for notoginseng roots, flying squirrel feces, typha pollen, corydalis tubers, Szechuan lovage rhizomes, common aucklandia roots, fennel, and borneol, in order to obtain fine powder, and the powder is uniformly mixed for standby; (2) medicinal powder obtained in the step (1) and a filler are uniformly mixed according to a weight ratio 0.5-1.5:0.5, a wetting agent is added, and granulation is carried out by extrusion with a wet method; (3) particles obtained in the step (2) are dried in a baking oven at 60 DEG C for 60 minutes, dried particles are obtained, particles are arranged and contained in capsules, and the capsules are obtained. The filler comprises starch, dextrin and lactose according to a weight proportion 7:1:1. The wetting agent comprises an ethanol alcohol whose weight percentage is 70% and a povidone solution whose weight percentage is 3%. The preparation method improves fluidity of products, solves the sticking problem, shortens disintegration time limit, and improves bioavailability.

Description

technical field [0001] The invention relates to the technical field of preparation methods of Chinese patent medicines. Background technique [0002] Tianqi Tongjing Capsules are included in Volume 10 of Chinese Medicine Prescriptions in the Drug Standards of the Ministry of Health of the People's Republic of China. After checking the information, it was found that the prescription was evolved from the ancient prescription "Shixiaosan". The prescription consists of Panax notoginseng, Wulingzhi, Puhuang, Corydalis Corydalis, Rhizoma Chuanxiong, Woody Fragrance, Cumin, and Borneol. Radix Notoginseng is good at removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain. It can not only stop bleeding, but also dissipate blood stasis. Ligusticum chuanxiong and Rhizoma Corydalis promote blood circulation and relieve pain; Wulingzhi and Puhuang remove blood stasis and stop bleeding, promote blood circulation and relieve pain. Muxiang promotes qi ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/48A61P15/00A61P29/00A61K35/24A61K31/045
Inventor 黄辉球
Owner 惠州市九惠制药股份有限公司
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