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Physalis angulata L. I as well as extraction method and application thereof

A kind of technology of picridin and extraction method, which is applied in the field of traditional Chinese medicine extraction, can solve the problems of extraction method and application that have not been reported yet, and achieve the effect of inhibiting tumor activity

Active Publication Date: 2016-10-12
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the extraction of Picropicrin I from Alopecia radiata, the extraction method, and its use have not been reported yet.

Method used

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  • Physalis angulata L. I as well as extraction method and application thereof
  • Physalis angulata L. I as well as extraction method and application thereof
  • Physalis angulata L. I as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The extraction method of acropicol I, comprises the steps:

[0033] (1) Take the dry stem and leaf (9.5kg) of bitter mulberry (Physalis angulata L.) as raw material, add 9 times the mass fraction of the raw material as a 75% ethanol aqueous solution, reflux extraction twice, each extraction for 2 hours, and combine to obtain Extract, solvent recovery under reduced pressure, obtain total extract (1370g) after concentrating;

[0034] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain 116g of ethyl acetate layer extract;

[0035] (3) The ethyl acetate layer extract was separated by silica gel column chromatography, and the dichloromethane-methanol with volume ratios of 100:1, 50:1 and 30:1 were used as gradient elution to obtain the fraction Fr.1 , Fr.2, Fr.3 (35g);

[0036] (4) Fraction Fr.3 was ...

Embodiment 2

[0049] The extraction method of acropicol I, comprises the steps:

[0050] (1) Take the dry stem and leaf of A. fraterna as a raw material, add 80% ethanol aqueous solution with a volume fraction of 8 mass times of the raw material, reflux extraction for 3 times, extract for 2 hours each time, combine to obtain the extract, recover the solvent under reduced pressure, and concentrate Obtain the total extract;

[0051] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0052] (3)-(8) are the same as embodiment 1(3)-(8).

Embodiment 3

[0054] The extraction method of acropicol I, comprises the steps:

[0055] (1) Take the dry stem and leaf of A. fraterna as a raw material, add 10 times the mass fraction of the raw material as a 60% ethanol aqueous solution, reflux extraction for 3 times, and extract for 2 hours each time, combine to obtain the extract, recover the solvent under reduced pressure, and concentrate Obtain the total extract;

[0056] (2) Disperse the total extract into 10 mass times of water, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0057] (3)-(8) are the same as embodiment 1(3)-(8).

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PUM

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Abstract

The invention discloses physalis angulata L. I as well as an extraction method and application thereof. The physalis angulata L. I has a structure of a formula (I) as shown in the description. The physalis angulata L. I is capable of effectively restraining release of nitrogen monoxide (NO), so that the compound disclosed by the invention can serve as an anti-inflammatory medicament. The physalis angulata L. I is capable of effectively restraining the tumor activity.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, and relates to picridin I, an extraction method and application. Background technique [0002] Physalis angulata L., also known as lantern grass, Tianpaozi, Tianpao grass, Pupu grass, Daebao, etc., is an annual herbaceous plant of the genus Physalis in the family Solanaceae. "Lu Chuan Materia Medica" and "Chinese Materia Medica" have detailed records on the medicinal effects of bitter fennel. Bitter bean has the functions of promoting qi, reducing swelling, diuresis, curing abdominal distension, clearing away heat and detoxification, diuretic and hemostasis, reducing swelling and dispelling stagnation, and can be used to treat throat Swelling and pain, lung abscess, mumps; dysuria, hematuria, gum swelling and pain, pemphigus and other diseases. Folks are mostly used to treat herpes, swollen gums, damp-heat jaundice, sore throat, lung-heat cough and other diseases. Scho...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K31/585A61K36/81A61P35/00A61P29/00A61P9/12A61P9/10A61P9/04A61P1/16A61P19/02A61P19/08A61P1/00A61P1/18A61P3/10A61P17/00A61P17/06A61P35/02A61P25/16A61P25/28A61P25/24A61P11/00A61P11/06A61P25/00
CPCA61K36/81C07J71/001
Inventor 邱峰孙成鹏陈丽霞康宁
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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