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A simple and efficient method for preparing nano-calcium phosphate

A nano-calcium phosphate and high-efficiency technology, applied in the field of biomedical materials, can solve the problems of difficult control of the nucleation and growth of calcium phosphate crystals, affecting the yield of nano-calcium phosphate, and increasing the preparation cost, so as to improve the biocompatibility, facilitate the The effect of large-scale production and simple preparation method

Inactive Publication Date: 2018-08-17
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Calcium phosphate crystal nucleation and growth is difficult to control due to its fast precipitation rate
Although it can be reduced by reducing Ca 2+ and PO 4 3- The method of reaction concentration and temperature reduces the reaction rate to better control its crystal nucleation and growth; but reducing the concentration and temperature will affect the yield of nano-calcium phosphate
The growth of nano-calcium phosphate crystals can also be controlled by adding surfactants, but the added surfactants may cause biocompatibility problems
In addition, the precipitation of calcium phosphate synthesized by wet method can easily lead to the formation of chemically bonded hard aggregates between particles during the drying process (Wang Midang, Li Mei, Liu Zhaogang, etc. Agglomeration mechanism, characterization and elimination of ultrafine powders. China Powder Body Technology, 2008,14(3):46-51); By adopting freeze-drying and supercritical drying methods, hard agglomeration can be avoided, which leads to a significant increase in its preparation cost

Method used

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  • A simple and efficient method for preparing nano-calcium phosphate
  • A simple and efficient method for preparing nano-calcium phosphate
  • A simple and efficient method for preparing nano-calcium phosphate

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Experimental program
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Embodiment 1

[0036] A simple and efficient method for preparing nanometer calcium phosphate, the steps are:

[0037] A. Prepare calcium salt solution and phosphate solution:

[0038] Dissolve calcium nitrate tetrahydrate in deionized water to obtain calcium salt solution; add ammonium dihydrogen phosphate (NH 4 H 2 PO 4 ) Dissolve in deionized water to obtain phosphate solution;

[0039] B. Wet synthesis of nanometer calcium phosphate:

[0040] Under the action of magnetic stirring, add neridronate sodium to the calcium salt solution to dissolve the neridronate sodium in the calcium salt solution; then at 37℃, drop the phosphate solution into the calcium salt solution to form Reaction system, while passing pH regulator—0.1mol / L NH 4 ·OH solution to make the pH of the reaction system 7.0; after the titration is completed, the molar ratio of calcium, sodium neridronate, and phosphorus in the reaction system is 0.5:0.01:1;

[0041] After the titration is completed, continue to stir for 30 minutes, and...

Embodiment 2

[0045] A simple and efficient method for preparing nanometer calcium phosphate, the steps are:

[0046] A. Prepare calcium salt solution and phosphate solution:

[0047] Dissolve calcium nitrate tetrahydrate in deionized water to obtain calcium salt solution; add ammonium dihydrogen phosphate (NH 4 H 2 PO 4 ) Dissolve in deionized water to obtain phosphate solution;

[0048] B. Wet synthesis of nanometer calcium phosphate:

[0049] Under the action of magnetic stirring, add opaldronate sodium to the calcium salt solution to dissolve the opaldronate sodium in the calcium salt solution; then at 37℃, drop the phosphate solution into the calcium salt solution to form Reaction system, while passing pH regulator—0.1mol / L NH 4 ·OH solution to make the pH of the reaction system 8.0; after the titration is completed, the molar ratio of calcium, sodium opaldronate and phosphorus in the reaction system is 1:0.01:1;

[0050] After the titration is completed, continue to stir for 120min, and pass t...

Embodiment 3

[0054] A simple and efficient method for preparing nanometer calcium phosphate, the steps are:

[0055] A. Prepare calcium salt solution and phosphate solution:

[0056] Dissolve calcium nitrate tetrahydrate in deionized water to obtain a calcium salt solution; add disodium hydrogen phosphate (Na 2 HPO 4 ) Dissolve in deionized water to obtain phosphate solution;

[0057] B. Wet synthesis of nanometer calcium phosphate:

[0058] Under the action of magnetic stirring, add alendronate sodium to the calcium salt solution to dissolve the alendronate sodium in the calcium salt solution; then drip the phosphate solution into the calcium salt solution at 37℃ to form Reaction system, while passing pH regulator—1.0mol / L NH 4 ·OH solution to make the pH of the reaction system 11.0; after the titration, the molar ratio of calcium, alendronate sodium and phosphorus in the reaction system is 1.67:0.02:1;

[0059] After the titration is completed, continue to stir for 30 minutes, and pass the pH adj...

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Abstract

A simple and efficient nano-calcium phosphate preparation method, the steps are: A, preparing calcium salt solution and phosphate solution: B, dissolving bisphosphonate in calcium salt solution; Drop into the calcium salt solution to form a reaction system, and at the same time adjust the pH of the reaction system to 7.0-11.0; the molar ratio of calcium, bisphosphonate and phosphorus in the reaction system is 0.50-1.67:0.01-0.02:1; after the titration is completed , continue to stir for 0-120min, and adjust the pH value of the reaction system to 7.0-11.0; then centrifuge and wash, filter, and then re-suspend the precipitate in absolute ethanol to obtain a suspension; C. Add bisphosphine to the suspension salt drug to obtain nano-calcium phosphate slurry, the molar ratio of bisphosphonate to phosphorus in the nano-calcium phosphate slurry is 0.01-0.02:1; then the nano-calcium phosphate slurry is rotated at a speed of 300-600r / min, and the time Ball milling for 4 to 12 hours, and finally drying the nano-calcium phosphate slurry to obtain nano-calcium phosphate powder.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to a method for preparing nanometer calcium phosphate simply and efficiently. Background technique [0002] Calcium phosphate is the main inorganic component of body bones and teeth. Studies have found that the ultrastructures of bones and teeth are composed of nanometer calcium phosphate, and nanometer calcium phosphate has many special physical and chemical properties such as surface effect, small size effect and high reactivity. , Nano calcium phosphate has attracted widespread attention. At present, nano-calcium phosphate is mainly used as a drug carrier for tumor targeted therapy and a gene carrier for disease diagnosis, and can also be used for the preparation of calcium phosphate artificial bone scaffolds. The constructed calcium phosphate scaffold has high mechanical strength and excellent biological properties. Since the construction of calcium phosphat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
CPCC01B25/325C01P2002/72C01P2002/85C01P2004/03C01P2004/04C01P2004/16
Inventor 屈树新高雪玲代春初刘玮玮肖雯
Owner SOUTHWEST JIAOTONG UNIV
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