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Low-molecular-weight polyglutamic acid, and preparation method and application thereof

A technology of polyglutamic acid and low molecular weight, which is applied in the field of low molecular weight polyglutamic acid and its preparation, can solve problems such as lack of targeted exploration, reduce the risk of clogging skin pores and sweat glands, and have excellent moisturizing performance , skin delicate effect

Active Publication Date: 2016-09-28
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, this study has still not been a targeted exploration to identify suitable low molecular weight polyglutamic acid for cosmetic moisture retention needs

Method used

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  • Low-molecular-weight polyglutamic acid, and preparation method and application thereof
  • Low-molecular-weight polyglutamic acid, and preparation method and application thereof

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Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of low molecular weight polyglutamic acid

[0038] Degradation is carried out with a polyglutamic acid aqueous solution with a concentration of 1% (w / v) as a reaction substrate. The degradation conditions are: pH 4.0, temperature 60°C, and holding time 1h to obtain a degradation product; add an alcohol reagent to the degradation product, When the alcohol content reaches 65% (w / w), a precipitate is formed, which is collected and dried to obtain low molecular weight polyglutamic acid.

[0039] Wherein, the aqueous solution of polyglutamic acid is an aqueous solution of sodium polyglutamate, and the relative average molecular weight of polyglutamic acid is 500 kDa. The alcohol reagent is ethanol.

Embodiment 2

[0040] Embodiment 2: Preparation of low molecular weight polyglutamic acid

[0041]Degradation is carried out with a polyglutamic acid aqueous solution with a concentration of 1.5% (w / v) as a reaction substrate. The degradation conditions are: pH 6.0, temperature 70°C, and holding time 3 hours to obtain a degradation product; add alcohol reagent to the degradation product, When the alcohol content reaches 80% (w / w), a precipitate is formed, which is collected and dried to obtain low molecular weight polyglutamic acid.

[0042] Wherein, the aqueous solution of polyglutamic acid is an aqueous solution of sodium polyglutamate, and the relative average molecular weight of polyglutamic acid is 700 kDa. The alcohol reagent is ethanol.

Embodiment 3

[0043] Embodiment 3: the preparation of low molecular weight polyglutamic acid

[0044] The aqueous solution of polyglutamic acid with a concentration of 2.0% (w / v) was used as the reaction substrate for degradation. The degradation conditions were: pH 5.0, temperature 68°C, and holding time 1.8 hours to obtain the degradation product; add alcohol reagent to the degradation product , so that the alcohol content reaches 68% (w / w), a precipitate is generated, and the precipitate is collected and dried to obtain low molecular weight polyglutamic acid.

[0045] Wherein, the aqueous solution of polyglutamic acid is an aqueous solution of sodium polyglutamate, and the relative average molecular weight of polyglutamic acid is 800 kDa. The alcohol reagent is ethanol.

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Abstract

The invention discloses a preparation method of low-molecular-weight polyglutamic acid. The method comprises the following steps: carrying out degradation by using a 1-6% polyglutamic acid water solution as a reaction substrate to obtain a degradation product, wherein the pH value is 1-6, the temperature is 60-120 DEG C, and the holding time is 1-8 hours; and adding an alcohol agent into the degradation product until the alcohol content reaches 65-91%, generating a precipitate, and collecting and drying the precipitate, thereby obtaining the low-molecular-weight polyglutamic acid. The invention also discloses application of the low-molecular-weight polyglutamic acid prepared by the method in preparing moisturizing cosmetics. A one-step process is used for degrading polyglutamic acid to obtain the degradation product within the specific molecular weight range without ultrafiltration or any other complicated after-treatment technique, thereby implementing complete utilization of the degradation product. The degradation product has excellent moisturizing property and lower viscosity, can be easily spread on the skin surface, reduces the risk of blocking the sweat pores and sweat gland pores, and is suitable for development and utilization of moisturizing cosmetics.

Description

technical field [0001] The invention belongs to the application field of polymer degradation, and in particular relates to a low-molecular-weight polyglutamic acid and its preparation method and application. Background technique [0002] Polyglutamic acid is the main component of the viscous colloid of natto, a natural traditional fermented food. It is a homogeneous polypeptide polymerized by glutamic acid through amide bonds. It can be prepared on a large scale through microbial fermentation and can be naturally degraded. It is a kind of Safe and environmentally friendly biopolymers. In the field of cosmetics, polyglutamic acid is a hydrophilic humectant, which can form a smooth, elastic, self-moisturizing soft film on the skin surface. However, since the relative average molecular weight of polyglutamic acid can be as high as 1000kDa, when it is applied to cosmetics and stays on the skin surface, especially in a humid environment or a lot of sweating, the polyglutamic aci...

Claims

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Application Information

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IPC IPC(8): C08J3/00A61K8/88A61K8/97A61Q19/00A61Q19/08
CPCA61K8/88A61K8/97A61Q19/00A61Q19/08C08J3/00C08J2377/04
Inventor 于林艳朱希强陈勉刘飞刘霞侯重文刘少英陈磊张金华王淼倪志坚凌沛学
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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