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Preparation method for tetrandrine and fangchinoline

A technology of tetrandrine A and B, which is applied in the field of drug preparation, can solve the problems of low preparation efficiency, high production cost, and complicated process, and achieve the effects of high extraction rate, convenient operation, and high purity

Inactive Publication Date: 2016-09-28
ZUNYI MEDICAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

The existing methods for preparing tetrandrine A and B have the common disadvantages of complicated process, high production cost and low preparation efficiency

Method used

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  • Preparation method for tetrandrine and fangchinoline
  • Preparation method for tetrandrine and fangchinoline
  • Preparation method for tetrandrine and fangchinoline

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with the embodiments and accompanying drawings, but the present invention is not limited to the following embodiments, and it can be foreseen that those skilled in the art may produce various changes in the implementation situation in combination with the prior art.

[0019] A preparation method of tetrandrine A and B, comprising the steps of:

[0020] 1) Separation of tetrandrine and B by medium-pressure silica gel column method: install a chromatographic column with a volume of 49mm×460mm, and the silica gel used for the chromatographic column is 300-400 mesh. The lipophilic tertiary amine total base was loaded into the column, and eluted with petroleum ether-ethyl acetate-diethylamine (9:1:0.1-5:1:0.1) at a flow rate of 80 mL / min. The liquid was checked by TLC, and those with the same components were combined. The solvent was recovered by a rotary evaporator to obtain two main components, Fr 1 and ...

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Abstract

The invention discloses a preparation method for tetrandrine and fangchinoline and belongs to the technical field of drug preparation. Lipotropy tertiary amine total alkali is adopted, and the preparation method comprises two steps that firstly, a medium pressure silica gel chromatography column method is used for separation, and elution is carried out through petroleum ether-ethyl acetate-diethylamine; secondly, purification is carried out through a preparation high performance liquid chromatography, methyl alcohol-water serves as a mobile phase, and finally, eluent is concentrated and evaporated to dryness. The method has the advantages that operation is convenient and quick and purity and the extraction rate are high.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of tetrandrine A and B. Background technique [0002] Fangji, also known as Fenfangji, Mountain Turtle, Stone Toad, and Falling Arch, is the dry root tuber of Fangji, a plant of the genus Fangji, containing polysaccharides, alkaloids, etc., and its main active ingredients are tetrandrine and Antihexine B. Tetrandrine has anti-inflammatory, analgesic, hypotensive, anti-tumor, anti-hypoxic pulmonary hypertension, and inhibition of pulmonary fibrosis effects. Tetrandrin is a natural calcium antagonist, which has therapeutic effects on hypertension, diabetes, liver fibrosis and other diseases, and also has brain cell protection and broad-spectrum anti-inflammatory and antibacterial effects. The existing methods for preparing tetrandrine A and B have the common disadvantages of complicated process, high production cost and low preparation efficiency. Content...

Claims

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Application Information

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IPC IPC(8): C07D491/18
CPCC07D491/18
Inventor 付少彬杨鸿强孟庆峰张茂生
Owner ZUNYI MEDICAL UNIVERSITY
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