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Synthetic method of polyglycollide

A synthesis method and polyglycolide technology, applied in the polymer field, can solve the problems of inability to carry out mass production, low relative molecular weight of polyglycolide, low conversion rate, etc., and achieve high intrinsic viscosity, uniform performance, The effect of high thermal stability

Inactive Publication Date: 2016-08-24
许智静
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the conversion rate of the preparation process of polyglycolide is low, and batch production cannot be carried out, and the relative molecular weight of the prepared polyglycolide is low

Method used

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Embodiment Construction

[0011] The present invention will be described in detail below in conjunction with specific embodiments.

[0012] A synthetic method for polyglycolide, comprising the steps of:

[0013] 1) Prepare chemically pure glycolide, stannous octoate with a molar fraction of 0.01%, and lauryl alcohol with a molar fraction of 0.01%;

[0014] 2) Glycolide, stannous octoate and lauryl alcohol are added to the reaction kettle for reaction, the reaction kettle is sealed and vacuumized, nitrogen gas is introduced, and the replacement is performed three times;

[0015] 3) After reacting for 30 minutes, the temperature of the reactor was rapidly raised to 160°C, and at the same time, the reactants in the reactor were stirred. After 45 minutes, the temperature inside the reactor was raised to 230°C at a rate of 1.67°C / min. After 105 minutes of reaction, the polymer was taken out. thing;

[0016] 4) Dry the polymer in vacuum at 30-35°C for 24 hours, extract the dried sample with ethyl acetate i...

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Abstract

The invention discloses a synthetic method of polyglycollide in the technical field of polymers. The synthetic method comprises the following steps: respectively preparing chemically pure diglycolide, stannous octoate of which the mole fraction is 0.01% and lauryl alcohol of which the mole fraction is 0.01%; adding the diglycolide, the stannous octoate and the lauryl alcohol into a reaction kettle for reaction, sealing and vacuumizing the reaction kettle, and introducing nitrogen into the reaction kettle; rapidly heating the reaction kettle to 160 DEG C after reacting for 30 minutes, starting stirring the reactants in the reaction kettle at the same time, heating the inside of the reaction kettle to 230 DEG C at a rate of 1.67 DEG C / min after 45 minutes, and taking out a polymer after reacting for 105 minutes; and performing vacuum drying on the polymer for 24 hours at 30-35 DEG C, performing extraction on a dried sample for 48 hours on soxhlet extractor by using ethyl acetate, and performing vacuum drying on the polymer for 24 hours at 30-35 DEG C. the polyglycollide prepared by the synthetic method disclosed by the invention is uniform in performance, can realize batch production, and is relatively high in conversion rate.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to a synthesis method of polyglycolide. Background technique [0002] In the prior art, polyglycolide is the first polymer material used for absorbable sutures, which has excellent mechanical properties, good biocompatibility and biodegradability, and has uniformity, stability, inertness And anti-gastric acid, gastric enzymes, infection, etc., and has the characteristics of non-toxic, no accumulation, minimal tissue reaction, etc., and has been widely used in clinical medicine. In the prior art, the conversion rate of the preparation process of polyglycolide is low, and mass production cannot be carried out, and the relative molecular weight of the prepared polyglycolide is low. Contents of the invention [0003] The purpose of the present invention is to provide a synthetic method of polyglycolide, so that it can realize batch production, improve conversion rate and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/85A61L17/10
Inventor 许智静
Owner 许智静
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