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Application of six-ingredient pomegranate tablets in preparation of drug for inhibiting cell proliferation of skin basal cell carcinoma cells A431

A technology of basal cells and cell proliferation, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problems of rough process, affecting clinical application, and many impurities

Inactive Publication Date: 2016-08-03
JINAN XINSHIDAI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Liuwei Pomegranate Tablets in the preparation of drugs for inhibiting the proliferation of human skin basal cell carcinoma A431 cells, and there is no report on the use of supercritical extraction in the extraction and preparation of Liuwei Pomegranate Tablets. The method is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 90g of pomegranate seeds, 45g of cinnamon, 45g of nutmeg, 45g of pepper, 45g of safflower, and 45g of Yunshi Datuoye, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 350min, and the supercritical extract is obtained. The supercritical extract is added to starch, and 70% ethanol is made into capsules, dried, and compressed into 500 tablets, each weighing 0.30g.

[0025] After testing, the content of piperine in the finished product is 8.05mg / tablet.

Embodiment 2

[0027] Take 90g of pomegranate seeds, 45g of cinnamon, 45g of nutmeg, 45g of pepper, 45g of safflower, and 45g of Yunshi Datuoye, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 300min, and the supercritical extract is obtained. The supercritical extract is added to starch, and 70% ethanol is made into capsules, dried, and pressed into tablets to make 500 tablets, each weighing 0.30g.

[0028] After testing, the content of piperine in the finished product is 4.15mg / tablet.

Embodiment 3

[0030] Take 90g of pomegranate seeds, 45g of cinnamon, 45g of nutmeg, 45g of pepper, 45g of safflower, and 45g of Yunshi Datuoye, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 400min, and the supercritical extract is obtained. The supercritical extract is added to starch, and 70% ethanol is made into capsules, dried, and pressed into tablets to make 500 tablets, each weighing 0.30g.

[0031] After testing, the content of piperine in the finished product is 6.03mg / tablet.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of six-ingredient pomegranate tablets in preparation of a drug for inhibiting cell proliferation of skin basal cell carcinoma cells A431 and a preparation method of the six-ingredient pomegranate tablets. The six-ingredient pomegranate tablets are prepared from 90 g of pomegranate seeds, 45 g of cortex cinnamomi, 45 g of nutmeg, 45 g of peppers, 45 g of flos carthami and 45 g of semen caesalpiniae cristae. The six-ingredient pomegranate tablets are prepared through supercritical extraction, and the content of piperine is greatly increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to the application of Liuwei Pomegranate Tablets in the preparation of medicines for inhibiting the proliferation of skin basal cell carcinoma cell A431 cells and the preparation method of Liuwei Pomegranate Tablets. Background technique [0002] The standard number of Liuwei Pomegranate Capsules is WS-10474 (ZD-0474)-2002, which is recorded in the Surgical and Gynecological Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made of 90g of pomegranate seeds, 45g of cinnamon, 45g of nutmeg, 45g of pepper, 45g of safflower, and 45g of Yunshi Datuo. It has the effects of warming the kidneys and warming the waist and knees. For women leucorrhea. [0003] In the prior art, there is no report on the application of Liuwei Pomegranate Tablets in the preparation of drugs for inhibiting the proliferation of human skin basal cell...

Claims

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Application Information

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IPC IPC(8): A61K36/67A61K9/20A61P35/00
CPCA61K36/185A61K9/2059A61K36/286A61K36/48A61K36/54A61K36/67A61K2236/37A61K2236/51A61K2300/00
Inventor 不公告发明人
Owner JINAN XINSHIDAI MEDICINE SCI & TECH
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