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Pharmaceutical composition containing paroxetine hydrochloride and application of pharmaceutical composition

A technology of paroxetine hydrochloride and a composition is applied in the field of pharmaceutical compositions containing paroxetine hydrochloride, which can solve the problems of large side effects and unsustainable drug effect, and achieve the effect of improving and improving the behavior of rats.

Inactive Publication Date: 2016-08-03
杨强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the technical deficiencies of existing antidepressants that have relatively large side effects and unsustainable drug effects, the present invention provides an antidepressant composition, which is composed of paroxetine hydrochloride and silybin

Method used

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  • Pharmaceutical composition containing paroxetine hydrochloride and application of pharmaceutical composition
  • Pharmaceutical composition containing paroxetine hydrochloride and application of pharmaceutical composition
  • Pharmaceutical composition containing paroxetine hydrochloride and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 compound tablet

[0022]

[0023] Preparation process: mix silibinin and paroxetine hydrochloride with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0024] The preparation of embodiment 2 compound tablet

[0025]

[0026] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0027] The preparation of embodiment 3 compound dispersible tablets

[0028]

[0029] Preparation process: Weigh silibinin and paroxetine hydrochloride according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP60% ethanol solution as adhesive Agent, micronized silica gel as a flow aid, granulated in one step in a fluidized bed, and then compressed into tablets.

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Abstract

The invention relates to a pharmaceutical composition containing paroxetine hydrochloride and its application, belonging to the technical field of medicine. In order to overcome the technical deficiencies of the existing antidepressants that have relatively large side effects and unsustainable drug effects, the present invention provides a pharmaceutical composition containing paroxetine hydrochloride, which consists of paroxetine hydrochloride and silybin. The pharmaceutical composition can significantly improve the behavioral score of depression rats when treating depression, and has a significant improvement effect on the cerebral cortex monoamine neurotransmitters of depression rats, thus playing a role in depression. Very good therapeutic effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing paroxetine hydrochloride and its application, belonging to the technical field of medicine. Background technique [0002] Depression is a mental disorder characterized by depressed mood, anhedonia, and decreased energy. Depression has a high incidence worldwide, and because severe depression is a disabling disease that can even lead to suicide, it is now a major burden on health care expenditures in all countries. [0003] The best-selling drugs in China’s antidepressant market are mainly dominated by imported joint venture drugs. Sino-US SmithKline’s paroxetine accounts for 84.20% of this type of drug market, Denmark’s Lundbeck oxalate escitalopram accounts for 78%, and Dalian Pfizer’s sertraline 88.18% of the drug market in this category. In addition, Suzhou Eli Lilly fluoxetine also occupies 93.85% of the drug market. Among the above-mentioned drugs, domestic manufacturers Zhejiang ...

Claims

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Application Information

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IPC IPC(8): A61K31/4525A61K9/20A61P25/24A61K31/357
CPCA61K31/4525A61K9/2013A61K31/357
Inventor 王晓岳
Owner 杨强
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