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A kind of supramolecular hydrogel factor, supramolecular hydrogel and preparation method thereof

A supramolecular hydrogel, factor technology, applied in gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve the problem of low biological activity, and achieve high reaction yield, short process, and good anti-tumor properties. Effect

Active Publication Date: 2018-11-09
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the bioactivity of this type of hydrogel is low, which has great limitations in medical applications.

Method used

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  • A kind of supramolecular hydrogel factor, supramolecular hydrogel and preparation method thereof
  • A kind of supramolecular hydrogel factor, supramolecular hydrogel and preparation method thereof
  • A kind of supramolecular hydrogel factor, supramolecular hydrogel and preparation method thereof

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Embodiment 1

[0042] One embodiment of the preparation method of supramolecular hydrogel factor and supramolecular hydrogel of the present invention comprises the following steps:

[0043] (1) Preparation of supramolecular hydrogel factors

[0044] Weigh 1.84g (6.71mmol) of ferrocenedicarboxylic acid, dissolve it in 250mL of anhydrous dichloromethane, slowly add 1.20g (8.88mmol) of 1-hydroxybenzotriazole (HOBt), 3.36g (8.86 mmol) benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU) and 1.80g (9.99mmol) phenylalanine methyl ester hydrochloride (H-PHe- OMe·HCl). Slowly add about 6 mL of triethylamine dropwise to adjust the pH of the solution to 8-9. The reaction was stirred at room temperature for 12h. Reaction was followed by thin layer chromatography (TLC) spot plate. After the reaction is completed, successively use saturated Na 2 CO 3 The aqueous solution, hydrochloric acid with a mass fraction of 5%, and distilled water were each extracted once, and the extracted d...

Embodiment 2

[0049] The glassy carbon electrode was polished with polishing powder (aluminum oxide powder), then ultrasonically washed twice with absolute ethanol and secondary water respectively, then rinsed with secondary water, and dried with nitrogen. A glassy carbon electrode was used as the working electrode, Ag / AgCl was used as the reference electrode, a platinum wire electrode was used as the counter electrode, and the electrolyte solution was PBS buffer solution (10 mmol / L, pH 7.4). At room temperature, with a scan rate of 0.05V / s, an initial potential of 0.3V, and a first reentry potential of 1.0V, the electrochemical data of the bare electrode was measured by cyclic voltammetry. The test results are shown in Image 6 Curve 1. Rinse the above-mentioned glassy carbon electrode with secondary water, dry it with nitrogen, drop 3 μL of the gel prepared in Example 1 above on the glassy carbon electrode, dry it at room temperature, and measure the hydrogel by the above-mentioned method...

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Abstract

The invention discloses a supramolecular hydrogel factor and a preparation method thereof. The supramolecular hydrogel factor molecularly comprises a ferrocene unit and two phenylalanine units. The ferrocene dicarboxylate and phenylalanine methyl ester hydrochloride are condensed under the action of an amide condensing agent and hydrolyzed under alkaline conditions to obtain the supramolecular hydrogel factor. The invention further discloses supramolecular hydrogel. The supramolecular hydrogel is obtained by self-assembly of the supramolecular hydrogel factor in a buffer solution with pH being 3-5 through noncovalent interaction. The supramolecular hydrogel has multiple stimulative responsibilities including pH responsibility, temperature responsibility, electrochemical responsibility and the like and is high in biocompatibility. Preparation methods of the supramolecular hydrogel factor and the supramolecular hydrogel are short in technical process, simple in operation, mild in reaction condition and high in reaction yield.

Description

technical field [0001] The invention belongs to the technical field of supramolecular self-assembly, and in particular relates to a supramolecular hydrogel factor, a supramolecular hydrogel and a preparation method thereof. Background technique [0002] Supramolecular hydrogels (Supramolecular hydrogels) refer to nano-aggregates formed by self-assembly of small molecules (molecular weight ≤ 2000, also known as gel factor) with water as the main solvent. This aggregate is a state in which the hydrophilic groups of the gelatin factor are dissolved in water and its hydrophobic groups are aggregated in water to achieve equilibrium. Different from traditional polymer gels, supramolecular hydrogels are formed through weak non-covalent interactions such as hydrogen bonds, hydrophobic interactions, and π-π stacking. Conditions such as ionic strength, electric field and magnetic field are used to achieve the reversible transition from solution to gel. Due to its unique physical act...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F17/02B01J13/00
CPCB01J13/0065C07F17/02
Inventor 张翼邹丽芬纪亚建
Owner CENT SOUTH UNIV
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