Extraction method of liquiritin compounds

An extraction method and compound technology, applied in the field of high-efficiency and high-yield extraction of licorice glycoside compounds, can solve the problems of increased labor and equipment costs, backward licorice extraction technology, and long extraction time, etc., to achieve fast extraction speed and process yield High, low dosage effect

Inactive Publication Date: 2016-07-20
刘良贵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current licorice extraction process is backward, the extraction rate is very low, and the extraction takes a long time, which undoubtedly increases the cost of labor and equipment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting licorice glycoside compounds, which uses licorice root as raw material to extract and produce, and the specific steps are as follows:

[0023] 1) Cleaning: Rinse licorice in a washing tank with cold water, or with industrially purified water.

[0024] 2) Crushing and grinding: After the raw materials are cleaned, they are crushed and ground in an industrial crushing device and a grinding device to break up the cells. The crushing and grinding process is carried out in a low temperature environment below 20°C .

[0025] 3) Separation of the slurry: the milled licorice cell slurry is filtered by a filter press or separated by a centrifuge to obtain the licorice cell slurry.

[0026] 4) Enzyme inactivation: the licorice cell slurry obtained in step 3) is subjected to an ultra-high temperature instantaneous inactivation of enzymes by using an ultra-high temperature instantaneous sterilization device process.

[0027] 5) Purification: Glycyrrhiza gl...

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PUM

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Abstract

The invention discloses an extraction method of liquiritin compounds.Radix glycyrrhiza serves as the raw material for extraction production.The extraction method includes the steps of 1, cleaning, wherein cold water or industrial purified water is adopted for rinsing; 2, breaking and milling, wherein rinsed glycyrrhiza is broken and milled to break cells; 3, serum separation, wherein a filter press or a centrifuge is adopted for separation, and glycyrrhiza cell serum is obtained; 4, enzyme deactivation, wherein a superhigh-temperature flash sterilization device process is adopted to perform superhigh-temperature flash sterilization on the glycyrrhiza cell serum; 5, purification, a macroporous resin adsorption and chromatographic separation process is adopted to adsorb and purify active materials such as liquiritin compounds in glycyrrhiza extract, and adsorption separation and purification are further performed to obtain high-concentration extraction liquor containing active ingredients such as liquiritin compounds; 6, concentration, wherein a vacuum concentration process is adopted to obtain concentrated liquor; 7, drying, wherein the concentrated liquor is atomized to obtain concentrate; 8, cooling, wherein the dry concentrate is cooled and subjected to agglomerating granulation, and the product can be obtained.

Description

technical field [0001] The invention relates to a method for extracting glycyrrhizin compounds from licorice with high efficiency and high yield, and belongs to the technical field of medicine extraction. Background technique [0002] Licorice (Glycyrrhizauralensis), also known as Ural licorice, is a perennial herb of the Fabaceae genus. There are bud marks on the surface of the roots and rhizomes, and pith in the middle of the cross-section. It tastes sweet and special. It is a kind of tonic Chinese herbal medicine. It is sweet in taste, flat in nature, and belongs to the twelve meridians. and other pharmacological effects. In traditional Chinese medicine, licorice invigorates the spleen and qi, relieves cough and moistens the lungs, relieves emergency and detoxifies, and harmonizes all kinds of medicines. The clinical application is divided into "raw use" and "honey-burning". Raw use mainly treats sore throat, gangrene sores, gastrointestinal ulcers, antidote poison, fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K125/00
Inventor 刘良贵
Owner 刘良贵
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