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Rare earth organic framework materials for fluorescence temperature sensing imaging inside biological tissues and cells and preparation methods thereof

A fluorescent temperature and biological tissue technology, applied in the direction of luminescent materials, chemical instruments and methods, preparations for in vivo experiments, etc., can solve the problems of difficult preparation of rare earth organic framework materials, insufficient color change, and insufficient temperature measurement sensitivity , to achieve high practical value, high temperature measurement sensitivity, and high temperature measurement sensitivity

Active Publication Date: 2017-10-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the biological field and other high-tech fields have very high requirements for the accuracy of temperature measurement. At present, the temperature measurement sensitivity of double rare earth organic framework materials in the physiological temperature range is still not high enough, and its color change with temperature is still not obvious enough. , still can not meet the requirements of practical application, so that the application of actual temperature measurement and imaging is limited
Moreover, the preparation of rare earth organic framework materials with small size is difficult, which further limits their application in the field of biomedicine.

Method used

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  • Rare earth organic framework materials for fluorescence temperature sensing imaging inside biological tissues and cells and preparation methods thereof
  • Rare earth organic framework materials for fluorescence temperature sensing imaging inside biological tissues and cells and preparation methods thereof
  • Rare earth organic framework materials for fluorescence temperature sensing imaging inside biological tissues and cells and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Using europium nitrate and terbium nitrate and 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine to synthesize micro-nano-scale rare earth organic framework materials by solvothermal method, and its specific synthetic route as follows:

[0029] With 0.0615mmol of europium nitrate and 0.0885mmol of terbium nitrate (molar ratio Eu 3+ :Tb 3+ =41:59), 0.075mmol of 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine and 0.9mmol of cetyltrimethylammonium bromide were dissolved in 36mL of In N,N-dimethylacetamide (DMA), another 7.2mL of methanol and 1.8mL of deionized water were added to form a mixed solution, and then the mixed solution was put into a closed glass bottle and heated at 105°C Reacted for 45 minutes under vigorous stirring, centrifuged and washed to obtain a micro-nano-scale rare earth organic framework material [Eu 0.41 Tb 0.59 L(DMA)(H 2 O)] (DMA) 3 ( figure 1 ), the size is about 1000nm, and the yield is 47.1%.

[0030] It can be obtained by single crystal X-ray diffra...

Embodiment 2

[0037] Utilizing europium acetate, terbium acetate and 2,4,6-tris(3-carboxyphenyl)-1,3,5-triazine to synthesize micro-nano-scale rare earth organic framework materials by solvothermal method, and its specific synthetic route as follows:

[0038] The europium acetate of 0.0015mmol and the terbium acetate of 0.1485mmol (molar ratio Eu 3+ :Tb 3+ =1:99), 0.075mmol of 2,4,6-tris(3-carboxyphenyl)-1,3,5-triazine and 0.9mmol of lauryl amidopropyl betaine were dissolved in 36mL of Add 7.2mL of methanol and 1.8mL of deionized water to N,N-dimethylformamide (DMF) to make a mixed solution, then put the mixed solution into a closed glass bottle, and put it at 40°C Reacted for 120 minutes under vigorous stirring to obtain a micro-nano-scale rare earth organic framework material [Eu 0.01 Tb 0.99 L 2 (DMF)(H 2 O)]·(DMF), the size is about 1000nm, and the yield is 47.1%.

[0039] It can be obtained by single crystal X-ray diffraction analysis, [Eu 0.01 Tb 0.99 L 2 (DMF)(H 2 O)]·(DMF...

Embodiment 3

[0043] Utilizing europium nitrate and terbium nitrate and 2,4,6-tris(3,5-dicarboxyphenyl)-1,3,5-triazine, a micro-nano-scale rare earth organic framework material was synthesized by a solvothermal method. The synthetic route of is as follows:

[0044] With 0.075mmol of europium nitrate and 0.075mmol of terbium nitrate (molar ratio Eu 3+ :Tb 3+ =1:1), 0.075mmol of 2,4,6-tris(3,5-dicarboxyphenyl)-1,3,5-triazine and 0.9mmol of potassium lauryl ether phosphate were dissolved in 36mL of N , into N-dimethylacetamide, add 7.2mL of methanol and 1.8mL of deionized water to make a mixed solution, then put it into a closed glass bottle, and react under vigorous stirring at 140°C for 20 minutes. Rare earth organic framework materials [Eu 0.5 Tb 0.5 L 3 (DMA)(H 2 O)] (DMA) 4 , the size is around 1000nm, and the yield is 47.1%.

[0045] It can be obtained by single crystal X-ray diffraction analysis, [Eu 0.5 Tb 0.5 L 3 (DMA)(H 2 O)] (DMA) 4 It has a long-range ordered crystal s...

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Abstract

The invention discloses a rare-earth organic framework material for fluorescent temperature sensation imaging in biological tissue and cells. The rare-earth organic framework material has the long-range ordered crystal structure and regular pores. The chemical formula is [LnLx(G)(H2O)].(G)n, wherein Ln is rare earth Eu or Tb, L is an organic ligand simultaneously containing benzene carboxylic acid group and triazinyl group, G represents a solvent molecule which is coordinated with rare-earth ions or in the crystal pores, x=1-3, and n=1-4. The rare-earth organic framework material is prepared by the solvothermal method which is simple and has higher yield. The micro / nano rare-earth organic framework material has the characterized light emissions of two types of rare-earth ions; the strength ratio of the two peaks has favorable exponential relation to the temperature; the temperature detection range is 20-80 DEG C; as the temperature increases, the luminous color can turn red from green; and the rare-earth organic framework material has favorable biocompatibility and heat stability, can implement real-time temperature imaging in biological tissues, and is hopeful to be applied in the aspects of biomedical treatment and the like.

Description

technical field [0001] The invention relates to a rare earth organic framework material and a preparation method thereof, in particular to a micro-nano-scale rare earth organic framework material and a preparation method thereof for fluorescent temperature sensing imaging inside biological tissues and cells. Background technique [0002] Temperature is a common and very important physical parameter, and the detection of temperature is of great significance to many scientific and technical fields. Especially in the field of biomedicine, the detection and control of temperature in human tissues or cells is crucial to the prevention and treatment of diseases. For example, when using high intensity focused ultrasound (HIFU, high intensity focused ultrasound) to remove tumors, the local temperature Detection and control are very important. If the temperature is too low, the desired therapeutic effect cannot be achieved, and if the temperature is too high, it will cause carbonizat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/00C09K11/06G01K11/00A61K49/00
CPCA61K49/0021C07F5/003C09K11/06G01K11/006
Inventor 崔元靖朱逢亮杨雨钱国栋
Owner ZHEJIANG UNIV
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