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Method for preparing succinimide with succinic acid fermentation liquor

A technology of succinimide and succinic acid, applied in the direction of organic chemistry, can solve the problems of pollution, high raw material cost, high energy consumption, etc., and achieve the effects of being environmentally friendly, less polluting, and simplifying the operation process

Active Publication Date: 2016-07-06
JIANGXI SCI & TECH NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a method for preparing succinimide by using succinic acid fermentation liquid, so as to solve the problem of high raw material cost and serious pollution in the preparation method of succinimide in the prior art , technical issues with high energy consumption

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  • Method for preparing succinimide with succinic acid fermentation liquor

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Embodiment 1

[0044]The fermentation broth fermented by the succinic acid-producing Escherichia coli genetically engineered bacteria was centrifuged and filtered, and then decolorized through an activated carbon decolorization column to obtain 1 L of clarified succinic acid fermentation broth. After the pretreated fermentation broth was acidified to adjust the pH<2 (the concentration of succinic acid was 105.37g / L), it was placed in a cooling crystallization tank at 4°C for 12 hours to crystallize. Filtrate to obtain the succinic acid solid (73.6 g of succinic acid obtained by vacuum drying) and the filtered mother liquor of succinic acid crystals. Add 85.2 g of urea to the filtered mother liquor of succinic acid crystallization, heat and stir to dissolve, then cool down to 4° C. for cooling and crystallization for 12 hours to obtain 56.8 g of urea succinic acid cocrystal after drying. Then the co-crystal was added to the reactor, and 73.6 g of succinic acid obtained by cooling and crystall...

Embodiment 2

[0046] The fermentation broth fermented by the succinic acid-producing Escherichia coli genetically engineered bacteria was centrifuged and filtered, and then decolorized through an activated carbon decolorization column to obtain 1 L of clarified succinic acid fermentation broth. Then acidify the pretreated fermented liquid to adjust the pH<2 (the concentration of succinic acid is 106.17g / L), put it into a cooling crystallization tank at 4° C. for 12 hours to crystallize. Filtrate to obtain succinic acid solid (73.7 g succinic acid obtained by vacuum drying) and succinic acid crystals and filtered mother liquor. Add 90 g of urea to the filtered mother liquor of succinic acid crystallization, heat and stir to dissolve, and then cool down to 4° C. for cooling and crystallization for 12 hours to obtain a co-crystal of urea succinate with a mass of 58.3 g after drying. Then put the co-crystal into the reaction kettle, add 73.7g of succinic acid obtained by cooling and crystalliza...

Embodiment 3

[0048] The fermentation broth fermented by the succinic acid-producing Escherichia coli genetically engineered bacteria was centrifuged and filtered, and then decolorized through an activated carbon decolorization column to obtain 1 L of clarified succinic acid fermentation broth. After the pretreated fermentation broth was acidified to adjust the pH<2 (the concentration of succinic acid was 103.25 g / L), it was cooled and crystallized at 4° C. for 12 hours, and the dried mass of succinic acid solid was 72.3 g. Then 100g of urea was added to the mother liquor after crystallization, heated and stirred to dissolve, and then cooled to 8°C for 12 hours to cool and crystallize to obtain a co-crystal of urea succinate with a mass of 55.4g after drying. Then 55.4g of co-crystals were added to the reaction kettle, 70g of succinic acid was added, and 1.2g of phosphorous acid solid was added, stirring was started and the temperature was raised to 135°C for 1 hour, and the temperature was ...

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Abstract

The invention provides a method for preparing succinimide with succinic acid fermentation liquor.With succinic acid obtained by microorganism fermentation and a product which is obtained by co-crystallizing urea in fermentation liquor being raw materials, succinimide is synthesized through control over the initial proportion of a succinic acid and urea reaction.The succinic acid component in the fermentation liquor can be effectively utilized without matching a succinic acid purification step independently, so that operation procedures are simplified; in addition, with the biological product being the initial raw material, pollution is small, remaining fermentation liquor in the process is free of harm to organisms, and can serve as biological fertilizer because residual urea components exist in the fermentation liquor, and CO2 generated by the synthesized succinimide can be used for microorganism culturing in the fermentation process of succinic acid.In this way, integration of a succinic acid separation technology and the succinimide synthesizing technology is achieved, the valuable intermediate product is obtained, additional value is increased on the basis of improving preparation efficiency, and meanwhile the requirement for environmental friendliness is met.

Description

technical field [0001] The invention relates to the technical field of biochemical industry, and further relates to a combined method of producing succinic acid by fermentation and chemically synthesizing succinimide, in particular to a method for preparing succinimide by using succinic acid fermentation broth. Background technique [0002] Bio-based succinic acid can be produced using cheap biomass such as potatoes and straws as raw materials, with high added value. At present, foreign companies such as Myriant and DSM have realized the industrialization of bio-based succinic acid. In China, there are also Nanjing University of Technology, Jiangnan University, Tianjin University, East China University of Science and Technology, Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, and the Institute of Process Technology of the Chinese Academy of Sciences. The unit conducts research on the production of succinic acid by biological fermentation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/404
CPCC07D207/404
Inventor 朱笃肖依文常军汪涯吴文婷
Owner JIANGXI SCI & TECH NORMAL UNIV
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