Traditional Chinese medicine aerosol composition for external use

Abstract

The invention provides a traditional Chinese medicine aerosol composition for external use.The traditional Chinese medicine aerosol composition is characterized by comprising a propellent and an ethanol extract of Chinese herbal medicine; the propellent is prepared from, by mass, 10%-45% of dimethyl ether, 5%-25% of tetrafluoroethane and 5%-25% of heptefluoro propane; in addition, 1%-12% of polyol is assisted to serve as cosolvent; the Chinese herbal medicine is mainly prepared from one or a mixture of herba of ajuga nipponensis makino, oriental stephania roots, illigera khasiana C.B.Clarke, borneol, roots of purging croton, radix zanthoxyli, rhizoma polygoni cuspidati, coral ardisia roots and roots of membranaceous beautyleaf, and extract solvent adopts mixed solvent of 90%-100% of ethanol and water.The aerosol composition is high in drug solubility, stable in physicochemical property, safe, environmentally friendly and significant in effect of treating traumatic injuries; the prepared aerosol is safe, environmentally friendly, stable in homogeneous phase, good in throwing performance and uniform in droplet dispersion; when the traditional Chinese medicine aerosol composition is used, the liquid medicine is sprayed to the wounded part directly, and the liquid medicine is safe and quick in effect.

Description

technical field [0001] The invention relates to an aerosol system prepared from an environment-friendly propellant and an ethanol traditional Chinese medicine extract, which belongs to the field of environmental chemical industry. Background technique [0002] The propellant, as the power source for spraying medicine, can make the aerosol spray out in the form of mist, and sometimes it can also act as a solvent or diluent for medicine at the same time. The propellant is mostly liquefied gas with low boiling point, and its vapor pressure at room temperature is greater than atmospheric pressure. When the lift actuator drives the valve to open, the propellant will gasify rapidly and generate pressure, which will disperse the drug into mist and spray it to the medication site . Therefore, when choosing a propellant, factors such as the form of use, pressure, compatibility, safety, stability, and cost of the spray must be considered. [0003] Until the early 1970s, Chloro-fluor...

AI Technical Summary

Problems solved by technology

For non-freon propellants, most of the currently used is isobutane, which has poor solubility and dispersibility for some Chinese herbal medicines, and isobutane has a low flash point and is flammable and explosive.

Chinese patent application 200410013526.X provides a cool and cooling aerosol prepared from dimethyl ether, water, antipruritic agent, flame retardant and spices. The propellant used is dimethyl ether, which is a flammable and explosive gas , although the flame retardant sodium borate is added, the addition of auxiliary materials may affect the use effect, and whether it can play a flame retardant effect has not been verified; Chinese patent application 200810207656.5 provides a - Aerosols prepared from tetrafluoroethane and / or 1,1,1,2,3,3,3-heptafluoropropane and lidocaine, except 1,1,1,2-tetrafluoroethane, 1 ,1,1,2,3,3,3-Heptafluoropropane is relatively expensive, and the cost of raw materials used is relatively high