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Small micro-fluidic chip system for biological particle parting analyzing

A microfluidic chip and particle technology, which is applied in the analysis of materials, instruments, etc., can solve the problems of large volume, complicated operation, and difficult integration of microfluidic chips, and achieve the effect of small size, high sensitivity, and no need for optical calibration.

Inactive Publication Date: 2016-06-22
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology

[0004] The purpose of the present invention is to provide a small microfluidic chip system for biological particle typing analysis in order to solve the problems of large volume, complicated operation and difficult integration with microfluidic chips in the prior art

Method used

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  • Small micro-fluidic chip system for biological particle parting analyzing
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  • Small micro-fluidic chip system for biological particle parting analyzing

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Embodiment 1

[0017] A small microfluidic chip system for the typing analysis of biological particles, such as image 3 As shown, it includes a sheath liquid microchannel 1, a sample microchannel 2, and a waste liquid microchannel 3; it also includes an excitation fiber channel 4, an excitation on-chip microlens 5, a collection on-chip microlens 6, and a collection fiber optic channel 7; On-chip microlens 5 and collecting on-chip microlens 6 are respectively placed on both sides of waste liquid microchannel 3; the optical axis of exciting on-chip microlens 5 is perpendicular to waste liquid microchannel 3; the optical axis of collecting on-chip microlens 6 Form an included angle with the waste liquid microchannel 3, and it is necessary to ensure that the angle of the included angle is not 90°; the excitation optical fiber channel 4 and the collection optical fiber channel 7 are set on the chip, wherein the excitation optical fiber channel 4 and the optical fiber of the excitation chip microl...

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Abstract

The invention relates to a small micro-fluidic chip system for biological particle parting analyzing and belongs to the field of biological sample detection.The small micro-fluidic chip system comprises an excitation fiber channel, an excitation slice carrying micro lens, a collection slice carrying micro lens and a collection fiber channel.The excitation slice carrying micro lens and the collection slice carrying micro lens are arranged on the two sides of a waste liquid microchannel respectively.The optical axis of the excitation slice carrying micro lens is perpendicular to the waste liquid microchannel.An included angle is formed between the optical axis of the collection slice carrying micro lens and the waste liquid channel.The excitation fiber channel and the collection fiber channel are formed in a chip.The micro-fluidic chip system is simple in structure, small in size, low in cost and power consumption, high in sensitivity, convenient to operate and free of optical calibration, and detection is accurate.A plurality of slice carrying micro lenses-fiber detection modules on the micro-fluidic chip can be machined to work in parallel, which helps to achieve high-flux detection.Therefore, the system is suitable for analyzing detection of a plurality of kinds of biological samples, especially for biological particles.

Description

technical field [0001] The invention relates to a small-sized microfluidic chip system for type analysis of biological particles, which belongs to the field of biological sample detection. Background technique [0002] Flow cytometry is a routine detection technique for typing analysis of biological particles, and is widely used in clinical diagnosis, biochemistry, biology and environmental monitoring and other fields. Although flow cytometry technology has been very advanced, traditional flow cytometers are bulky, have high power consumption, are expensive, and are cumbersome to operate. These devices cannot function normally in some extreme environments and conditions, such as emergency rescue, Space station, border post, remote village, etc. Miniaturized total analysis system (μ-TAS), also known as Laboratory-on-a-Chip (LOC for short), was first proposed by Manz and Widmer of CibaGeigy in Switzerland in 1990, and has developed rapidly since then. After decades of develo...

Claims

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Application Information

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IPC IPC(8): G01N35/00
CPCG01N35/00
Inventor 李勤赵莹莹胡晓明辛怡
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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