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Method for preparing tablet medicine on basis of ink-jet 3D printing technology

A 3D printing and drug preparation technology, applied in drug combinations, pharmaceutical formulations, antipyretics, etc., can solve problems such as inability to achieve precise and controlled release, prone to splintering, disintegration, and lack of personalization. Realize the effect of personalization, solving disintegration, and shaping

Inactive Publication Date: 2016-06-22
NORTHWESTERN POLYTECHNICAL UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0007] Therefore, in order to overcome the low effective utilization rate of the traditional preparation of tablet medicaments, the individuation is not prominent, the precise controlled release cannot be well realized, and the manufacturing process is prone to problems such as splitting and collapsing. A new method of 3D printing medicine as a base material while spraying a binder on the base material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The following describes the embodiments of the present invention in detail, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0031] This implementation example selects and prepares compound aspirin tablet as example. Compound aspirin tablets are mainly used for fever, headache, neuralgia, toothache, menstrual pain, muscle pain, joint pain. The main ingredients are: each tablet contains 0.22g of acetylsalicylic acid, 0.15g of phenacetin, and 0.035g of caffeine.

[0032] The specific implementation steps are:

[0033] Step 1: Create a layered 3D CAD model of the compound aspirin tablet:

[0034] Step 1.1: Carry out three-dimensional scanning to compound aspirin tablet and export STL file, import STL file in CAD software, obtain the three-dimensional CAD model of compound aspirin tablet;

[0035] Step 1.2: Divide the 3D model of compound aspirin tablet imported into CAD into...

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Abstract

The invention provides a method for preparing tablet medicine on the basis of an ink-jet 3D printing technology. The method comprises the following steps: firstly, carrying out 3D scanning on the medicine, building a three-dimensional model of the medicine, and carrying out hierarchical processing on the model; then, mixing main ingredients and auxiliary materials required for printing the medicine at a certain ratio, and pressing the mixture into medicine powder; finally, evenly spreading the mixed medicine on a forming platform through 3D printing equipment, and spraying one layer of biological adhesive with good biodegradability on each layer of medicine powder. The method controls the ratio of the auxiliary materials and the main ingredients in the medicine powder as well as the kinds and the contents of biological adhesives, and combines with the excellent characteristics of the 3D technology to control the structure, the ingredients and the like of the printed medicine, the effective dispersion speed and gradient of the tablet is quantitatively regulated and controlled, and speed for the main ingredients to enter blood and the effective use ratio of the medicine are changed.

Description

technical field [0001] The invention relates to the technical field of tablet medicine preparation, in particular to a method for preparing tablet medicine based on inkjet 3D printing technology. Background technique [0002] The pharmaceutical preparations currently used in the market mainly include several forms such as tablets, oral liquids, and capsules, among which tablets occupy a large proportion. The preparation of tablet medicaments by the traditional process adopts the method of batch compression production, that is, for the same batch of medicaments, the contents of the main ingredients and auxiliary ingredients in the medicine are all constant. However, in actual disease diagnosis, different patient populations have different drug requirements (for example, for the same disease, the elderly and children need relatively smaller drug intake than adults), so it is necessary to Personalization during preparation. [0003] Tablet refers to the sheet-shaped preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/616A61P29/00A61K31/167A61K31/522
CPCA61K9/2054A61K9/2095A61K31/167A61K31/522A61K31/616A61K2300/00
Inventor 汪焰恩王淑志魏庆华李欣培杨明明柴卫红王凯
Owner NORTHWESTERN POLYTECHNICAL UNIV
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