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Application of self-assembled micelles of amphiphilic copolymer containing thymine as emulsifier

A technology of thymine and copolymer, which is applied in the directions of medical preparations containing active ingredients, preparations for skin care, and medical preparations without active ingredients, etc., to achieve the effect of strong salt resistance

Active Publication Date: 2019-03-22
科斯迈(武汉)生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few reports on self-assembled micelles using thymine-containing amphiphilic copolymers as emulsifiers

Method used

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  • Application of self-assembled micelles of amphiphilic copolymer containing thymine as emulsifier
  • Application of self-assembled micelles of amphiphilic copolymer containing thymine as emulsifier
  • Application of self-assembled micelles of amphiphilic copolymer containing thymine as emulsifier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of PSVM polymer self-assembled micelles

[0034] Amphiphilic copolymers PSVM1-PSVM4 with thymine contents of 4.48wt%, 9.42wt%, 20.24wt%, and 25.73wt% were dissolved in the solvent DMF to obtain a polymer solution with a mass concentration of 50 mg / mL. Add deionized water dropwise at a rate of 30 μL / min until blue opalescence appears, stop adding water, continue stirring for 3 h, drop the blue opalescent solution into a large amount of deionized water under stirring conditions to fix the micellar structure, and then After stirring for 3 hours, the solution was transferred to a dialysis bag, dialyzed with deionized water for 5 days, and the water was changed every 6 hours to remove DMF, and the finally obtained four PSVM micellar aqueous solutions were adjusted to the desired concentration.

[0035] (2) Preparation of PSVM self-assembled micelles stabilized emulsion

[0036] Set the concentration of the four micellar aqueous solutions PSVM1-PSVM4 to 2mg / m...

Embodiment 2

[0039] (1) Preparation of PSVM polymer self-assembled micelles

[0040] Dissolve the thymine-containing amphiphilic copolymer PSVM in the solvent DMF to obtain a polymer solution with a mass concentration of 50 mg / mL, add deionized water dropwise to it at a rate of 30 μL / min under magnetic stirring until blue opalescence appears, and stop Add water, continue to stir for 2 hours, drop the blue opalescent solution drop by drop into a large amount of deionized water under stirring conditions to fix the micellar structure, and then transfer the solution to a dialysis bag after stirring for 3 hours, and dialyze with deionized water for 5 days. The water was changed every 6 hours to remove DMF, and the finally obtained aqueous solution of PSVM micelles was adjusted to the desired concentration.

[0041] (2) Preparation of PSVM self-assembled micelles stabilized emulsion

[0042] Take 3mL prepared micellar aqueous solutions with different concentrations (0.2-5mg / mL) and white oil of...

Embodiment 3

[0045] (1) Preparation of PSVM self-assembled micelles, the method is the same as step (1) in Example 2.

[0046] (2) Preparation of PSVM self-assembled micelles stabilized emulsion

[0047] Set the concentration of the micellar aqueous solution to 2mg / mL, use a small amount of HCl and NaOH to adjust the pH of the micellar aqueous solution to 3.61-11.00, take 3mL of PSVM micellar aqueous solution with different pH and an equal volume of white oil in an emulsification bottle, Use a high-speed disperser to homogenize for 2 minutes at a speed of 20,000 r / min, and after standing for 24 hours, the desired emulsion is obtained.

[0048] image 3 Digital photographs and optical microscope images of PSVM micelles stabilized at different pH. It can be seen from the figure that when the pH ≤ 4.62, a stable oil-in-water emulsion can be formed, and the particle size of the emulsion increases with the increase of pH; when the pH ≥ 5.55, the emulsion breaks. Therefore, the formation and ...

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Abstract

The invention relates to application of amphiphilic copolymer self-assembled micelle containing thymine as emulgator. The amphiphilic copolymer self-assembled micelle containing thymine can be stably dispersed on an oil-water interface and serves as particles emulsifier to stabilize an oil-water system to form emulsion; the prepared emulsion has pH responsiveness, high salt resistance and long-term stability; the amphiphilic copolymer self-assembled micelle containing thymine serves as the emulsifier, can be used independently or used by being compounded with other types of emulsifier and can be applied to such fields as cosmetics or biological medicine.

Description

technical field [0001] The invention relates to the technical field of emulsifiers, in particular to the application of self-assembled micelles of thymine-containing amphiphilic copolymers as emulsifiers to stabilize oil-water systems to prepare emulsions. Background technique [0002] As early as the beginning of the last century, Ramsden and Pickering found that micron-sized solid particles can be adsorbed at the oil-water interface to form a particle film to prevent emulsion droplets from coalescing. This solid particle is called a "particle emulsifier", and its stable emulsion Called "Pickering Emulsion". Pickering emulsion has the advantages of super stability, low foaming, and low toxicity. It is widely used in the fields of medicine, food, cosmetics, sewage treatment, and oil recovery. Due to the excellent structural controllability of amphiphilic copolymer micelles, the emulsification effect of amphiphilic copolymer micelles as particle emulsifiers has attracted ext...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/06A61K47/32A61K9/107A61Q19/00
CPCA61K8/06A61K8/8164A61K9/107A61K47/32A61K2800/10A61Q19/00
Inventor 刘敬成谢亚珍王宽刘仁袁妍刘晓亚
Owner 科斯迈(武汉)生物科技有限责任公司
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