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Techniques used for laser cutting endothelial corneal grafts

An endothelial cornea, laser cutting technology, applied in laser surgery, ophthalmic surgery and other directions, can solve the problems of endothelium cannot be repaired, damaged, and cannot be regenerated.

Inactive Publication Date: 2018-06-29
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, manual removal of Bowman's membrane and endothelium with the aid of a mechanical trephine and subsequent Bowman's stripping for DMEK can easily lead to irreparable damage to the endothelium, which cannot regenerate

Method used

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  • Techniques used for laser cutting endothelial corneal grafts
  • Techniques used for laser cutting endothelial corneal grafts
  • Techniques used for laser cutting endothelial corneal grafts

Examples

Experimental program
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Embodiment Construction

[0045] figure 1 A laser system 100 equipped to allow a surgeon to fabricate an endothelial graft from a cadaveric donor cornea is schematically shown. The laser system 100 includes a laser cutting device 102 and a support unit 116 . The laser cutting device 102 includes a laser radiation source 104, focusing and deflection optics 106, and a laser cutting interface 108 (sometimes referred to as a patient interface or adapter when the laser cutting device 102 is used for laser treatments). The laser cutting device 102 also includes a control unit 110 including a control program 112 .

[0046] Source 104 produces pulsed laser radiation 113 propagating along optical axis 114 . Laser pulses have pulse durations in the attosecond, femtosecond, picosecond or nanosecond range. The energy density (i.e., fluence) and intensity of the pulses are suitably selected to irradiate a specific tissue location with a predetermined number of pulse(s) to achieve photodisruption (which includes ...

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Abstract

A method for making an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea with laser radiation from an endothelial side of the donor cornea to cause photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving said focus of said radiation to form an endothelial graft in said donor cornea. Cutting the endothelial graft by irradiating the donor cornea from the endothelial side rather than the epithelial side, the optical inhomogeneity created in the stromal tissue of the donor cornea after death makes the laser The cutting process is largely unaffected.

Description

technical field [0001] The present disclosure generally relates to a technique for making an endothelial keratoplasty. More specifically and without limitation, a technique for isolating at least Descemet's membrane from a donor cornea including a corneal stroma is disclosed. Background technique [0002] In addition to traditional full thickness penetrating keratoplasty (PKP), eyes with permanent endothelial damage leading to poor vision can be treated by replacing the diseased portion of the cornea while maintaining the healthy front portion of the cornea. [0003] Posterior lamellar keratoplasty (PLK) was proposed by José I. Barraquer and Charles Tillett in the 1950s. The need for precisely shaped corneal grafts increased in the late 1990s, when it was demonstrated that surgically removed corneal discs containing diseased endothelium could be replaced by similar partial-thickness donor discs and that the discs could be removed without Attached to the inner corneal surfa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/008
CPCA61F9/00831A61F2009/00853A61F2009/00872
Inventor C·多尼茨基T·西勒
Owner NOVARTIS AG
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