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Traditional Chinese medicine for preventing and treating leukopenia after lung cancer chemotherapy

A technology for leukopenia and traditional Chinese medicine, which can be used in extracellular fluid diseases, sugar-coated pills, drug combinations, etc., and can solve problems such as dose-limiting toxicity, clinical application limitations, and affecting chemotherapy.

Inactive Publication Date: 2016-05-11
QINGDAO HUAZHICAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy is one of the main treatment methods for nongerminoma (NSCLC), but most of the chemotherapeutic drugs are cytotoxic drugs, which can cause great damage to normal tissue cells with active metabolism, such as bone marrow stem cells, while killing tumor cells. Different degrees of bone marrow suppression, manifested as a decrease in the number of peripheral blood leukocytes, is a dose-limiting toxicity of chemotherapy, which can affect the smooth progress of chemotherapy and lead to interruption of chemotherapy and radiotherapy
[0003] The measures for clinical treatment and prevention of leukopenia after chemotherapy for lung cancer include oral administration of leucogen, batyl alcohol, etc., and subcutaneous injection of recombinant human granulocyte colony-stimulating factor, etc., but all have different degrees of application limitations. Recombinant human granulocyte colony-stimulating factor The effect is acceptable, but there are disadvantages such as high price and many adverse reactions, so the clinical application is limited to a certain extent

Method used

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  • Traditional Chinese medicine for preventing and treating leukopenia after lung cancer chemotherapy
  • Traditional Chinese medicine for preventing and treating leukopenia after lung cancer chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription: 20 parts of Codonopsis, 20 parts of Astragalus, 12 parts of Atractylodes macrocephala, 12 parts of galangal, 20 parts of Chinese jujube, 12 parts of Caulis Spatholobus, 4 parts of Ziheche and 4 parts of Achyranthes bidentata.

[0030] Preparation method:

[0031] 1) Weigh Ziheche and Achyranthes bidentata, dry and pulverize, pass through a 120-mesh sieve to obtain fine powder;

[0032] 2) Weigh Codonopsis pilosula, Astragalus membranaceus, Atractylodes macrocephala, Galangal, Jujube and Millipede spatholobus, crush them into coarse powder, mix well, add 8-10 times the amount of water to extract twice, each time for 1-2 hours, combine the filtrates, and decompress Concentrate, dry, and crush through a 120-mesh sieve to obtain the water extract.

[0033] 3) Mix the fine powder obtained in step 1) and the water extract obtained in step 2) uniformly, granulate, and fill capsules to obtain capsules, so that each capsule contains 0.5g of crude drug.

Embodiment 2

[0035] Prescription: 16 parts of Codonopsis, 16 parts of Astragalus, 8 parts of Atractylodes macrocephala, 8 parts of galangal, 8 parts of jujube, 8 parts of Caulis Spatholobus, 4 parts of Ziheche and 4 parts of Achyranthes bidentata.

[0036] Preparation method:

[0037] 1) Weigh Ziheche and Achyranthes bidentata, dry and pulverize, pass through a 100-mesh sieve to obtain fine powder;

[0038] 2) Weigh Codonopsis pilosula, Astragalus membranaceus, Atractylodes macrocephala, Galangal, Jujube and Millipede spatholobus, crush them into coarse powder, mix well, add 8-10 times the amount of water to extract twice, each time for 1-2 hours, combine the filtrates, and decompress Concentrate, dry, and crush through a 100-mesh sieve to obtain the water extract.

[0039] 3) Mix the fine powder obtained in step 1) and the water extract obtained in step 2) uniformly, granulate, and fill capsules to obtain capsules, so that each capsule contains 0.5g of crude drug.

Embodiment 3

[0041] Prescription: 12 parts of Codonopsis, 12 parts of Astragalus, 4 parts of Atractylodes macrocephala, 4 parts of galangal, 8 parts of jujube, 16 parts of Caulis Spatholobus, 2 parts of Ziheche and 6 parts of Achyranthes bidentata.

[0042] Preparation method:

[0043] 1) Weigh Ziheche and Achyranthes bidentata, dry and pulverize, pass through a 120-mesh sieve to obtain fine powder;

[0044] 2) Weigh Codonopsis pilosula, Astragalus membranaceus, Atractylodes macrocephala, Galangal, Jujube and Millipede spatholobus, crush them into coarse powder, mix well, add 8-10 times the amount of water to extract twice, each time for 1-2 hours, combine the filtrates, and decompress Concentrate, dry, and crush through a 120-mesh sieve to obtain the water extract.

[0045] 3) Mix the fine powder obtained in step 1) and the water extract obtained in step 2) evenly, make granules, add 1% magnesium stearate, mix evenly, press into tablets, and coat with sugar to obtain tablets with a crude...

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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to traditional Chinese medicine for preventing and treating leukopenia after lung cancer chemotherapy. The traditional Chinese medicine comprises hairy asiabell roots, radix astragali, rhizoma atractylodis macrocephalae, rhizoma alpiniae officinarum, Chinese dates, caulis spatholobi, dried human placenta and radix achyranthis bidentatae. The whole prescription of the traditional Chinese medicine can be used for tonifying qi, lifting yang and supporting healthy energy and achieves the effects of replenishing qi, nourishing blood, strengthening the spleen and stomach and nourishing the liver and kidney in a synergistic mode. Clinical verifications show that the traditional Chinese medicine can alleviate generation of myelosuppression and has the effects of enhancing immunity of the human body and increasing white blood cells.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine for treating and preventing leukopenia after chemotherapy for lung cancer. Background technique [0002] Lung cancer is one of the cancers with the highest morbidity and mortality in the world, of which 80% are non-small cell lung cancers. Over the past 50 years, the morbidity and mortality of lung cancer have risen rapidly in countries all over the world, especially in industrialized countries, and lung cancer has ranked first among male patients who died of cancer. Chemotherapy is one of the main treatment methods for nongerminoma (NSCLC), but most of the chemotherapeutic drugs are cytotoxic drugs, which can cause great damage to normal tissue cells with active metabolism, such as bone marrow stem cells, while killing tumor cells. Different degrees of bone marrow suppression, manifested as a decrease in the numbe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P7/00A61K35/50
CPCA61K9/1623A61K9/2813A61K9/2826A61K35/50A61K36/21A61K36/284A61K36/344A61K36/481A61K36/486A61K36/725A61K36/9062A61K2300/00
Inventor 刘学键
Owner QINGDAO HUAZHICAO PHARMA CO LTD
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