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Application of obaculactone in preparation of drugs for treating pulmonary fibrosis, chronic pneumonia and chronic respiratory disease and drugs prepared from obaculactone

A technology of pulmonary fibrosis and Phellodendron lactone, applied in respiratory diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as damage, damage factors persist, and the effect is yet to be clinically tested, so as to improve inflammatory symptoms and reduce hydroxyproline Amino acid content, the effect of improving lung damage

Active Publication Date: 2016-05-11
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the third stage, the injury factor persists, causing repeated injuries
Pirfenidone, which has just been approved by the FDA, is currently the only drug for the treatment of pulmonary fibrosis, and its effect has yet to be clinically tested

Method used

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  • Application of obaculactone in preparation of drugs for treating pulmonary fibrosis, chronic pneumonia and chronic respiratory disease and drugs prepared from obaculactone
  • Application of obaculactone in preparation of drugs for treating pulmonary fibrosis, chronic pneumonia and chronic respiratory disease and drugs prepared from obaculactone
  • Application of obaculactone in preparation of drugs for treating pulmonary fibrosis, chronic pneumonia and chronic respiratory disease and drugs prepared from obaculactone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] 1. Pharmacological test of phellodendron lactone

[0030] 1) Induction of pulmonary fibrosis model induced by chronic pneumonia in mice

[0031] Animal model of bleomycin-mediated pulmonary fibrosis in mice (tracheal instillation method)

[0032] Dissolve bleomycin (titer 15 mg / bottle) with 1 mL of sterilized phosphate buffered saline (PBS) to a 15 mg / mL stock solution, and store in a 4-degree refrigerator. On the day of the experiment, take a pre-calculated 15 mg / mL stock solution and dilute it to 2 mg / mL with sterile PBS. About 25 g mice were anesthetized by intraperitoneal injection of about 180 μL of 1% pentobarbital sodium (diluted in PBS). Then the mouse was fixed on the mouse board, and the teeth of the mouse were hooked along the top of the mouse head with a surgical thread to keep the trachea straight. After alcohol disinfection, carefully cut the skin at the trachea, the opening is about 1 cm long, and then carefully peel off the trachea from the tissue wit...

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Abstract

The invention discloses application of obaculactone in preparation of drugs for treating pulmonary fibrosis, chronic pneumonia and chronic bronchitis and a chronic obstructive pulmonary disease or asthma, and further discloses the related drugs. Obaculactone can effectively and dose-dependently improve the bleomycin-induced mouse pulmonary fibrosis damage and the inflammation symptoms generated in the pathogenic process of the mouse pulmonary fibrosis damage through oral administration. Detection on collagen synthesis shows that obaculactone can dose-dependently regulate down generation of alpha-SMA and collagen, and the effect is based on inhibition of obaculactone on a TGF-beta signal channel in the mouse pulmonary fibrosis tissue. The results show that obaculactone can be applied to multiple inflammation-mediated chronic lung diseases including the pulmonary fibrosis, the chronic pneumonia, silicosis, the chronic bronchitis, the chronic obstructive pulmonary disease and the asthma.

Description

technical field [0001] The invention relates to the application of phellodendron lactone in the preparation of medicines for treating pulmonary fibrosis and chronic pneumonia, and belongs to the technical field of pharmacy. Background technique [0002] Pulmonary fibrosis is a general term for a large group of diseases. Medically, pulmonary fibrosis is classified as pulmonary interstitial disease. Pulmonary interstitial fibrosis is a common pathological process after lung tissue injury, manifested as early diffuse alveolitis, later Excessive proliferation of fibroblasts and excessive deposition of extracellular matrix can cause respiratory failure with a mortality rate as high as 50%-70%. There are many reasons for pulmonary fibrosis, such as environmental, occupational, physical and chemical factors, such as asbestos, minerals, dust, chemotherapy drugs, radiation damage, etc. Some rheumatic immune diseases can also be accompanied by pulmonary fibrosis. Pulmonary fibrosis i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P11/00A61P11/06
CPCA61K31/585
Inventor 徐强吴雪丰孙洋王兴启沈燕吴旭东罗琼金彪
Owner NANJING UNIV
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