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Novel method for detection of codeine based on ionic iridium complex electrochemiluminescence and molecular imprinting recognition

A technology of molecular imprinting and iridium complexes, applied in the fields of photochemistry, materials science, and electrochemistry, can solve problems such as insufficient selectivity

Active Publication Date: 2016-05-04
JIANGNAN UNIV
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Problems solved by technology

[0004] The sensor prepared only by immobilizing the iridium complex has high sensitivity and good reproducibility, but the selectivity is slightly insufficient

Method used

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  • Novel method for detection of codeine based on ionic iridium complex electrochemiluminescence and molecular imprinting recognition
  • Novel method for detection of codeine based on ionic iridium complex electrochemiluminescence and molecular imprinting recognition
  • Novel method for detection of codeine based on ionic iridium complex electrochemiluminescence and molecular imprinting recognition

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example 1

[0046] The linear relationship and detection limit of the MIP-ECL sensor: Under the optimized experimental conditions, the response to different concentrations of codeine solutions was tested, and the electrochemiluminescence performance of the ECL-MIP sensor was tested in the appendix Figure 7 . As the concentration of codeine continues to increase, the intensity of the electrochemiluminescence signal also shows an increasing trend, but the luminescence intensity value does not directly form a linear relationship with the concentration of codeine, and it needs to take the logarithm of the concentration of codeine to form Very good linear relationship, the linear range is 1.0×10 -11 ~5.0×10 -9 mol L -1 . The regression equation is I ECL =11.21logC+127.98, r=0.9962, the detection limit reached 9.23×10 - 12 mol / L (S / N=3). pair 1.0×10 -10 mol L -1 The codeine solution was subjected to repeated experiments (n=7), and the calculated relative standard deviation (RSD) was 5...

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Abstract

The invention discloses a method for rapid detection of codeine based on combination of ionic iridium complex electrochemiluminescence and molecular imprinting recognition technologies. The method comprises the steps: firstly, preparing a composite solution from a cation exchange agent Nafion, multi-walled carbon nanotubes and an ionic iridium complex, taking a proper amount of the composite solution, and dropwise coating the surface of an electrode with the composite solution, to obtain a [(bpq-OCH3)2Ir(dcbpy)]<+>PF6<-> / MWCNT / Nafion electrochemiluminescence modified electrode; and then preparing a molecularly imprinted layer on the modified electrode by using an electro polymerization method. Codeine is detected based on the ionic iridium complex electrochemiluminescence and electro polymerization molecular imprinting recognition for the first time, the sensitivity is relatively high, the selectivity is good, good linear property exists at 1.0*10<-11>-5.0*10<-9> mol*L<-1>, the linear equation is I[ECL]=11.21logC+127.98 (r=0.9962), and the detection limit reaches 9.23*10<-12> mol*L<-1> (S / N=3).

Description

technical field [0001] The invention discloses a novel detection method for codeine based on electrochemiluminescence-electropolymerization molecular imprint recognition of ionic iridium complexes, and relates to the fields of material science, photochemistry, electrochemistry and the like. Background technique [0002] Codeine, also known as methylmorphine phosphate. It is widely used in pathological and physiological aspects, such as curing cough, sedation, and pain relief; but it is also included in the category of drugs and is an important object of prohibition. Common detection methods for this substance include gas chromatography-ultraviolet-visible coupling, gas chromatography-mass spectrometry, and high performance liquid chromatography-mass spectrometry, but the detection level of these analytical methods is limited to the micromolar level [1-4] , and the instrument is huge, takes a long time, and its use is limited in some aspects. Recently, Chen Xi's research gr...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/76
CPCG01N21/76
Inventor 许春华李彤彤宋启军宋星辰
Owner JIANGNAN UNIV
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