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Novel medicinal application of coreopsis tinctoria

A technology of snow chrysanthemum and medicine, applied in a new application field in medicine, can solve the problems such as application and research of hyperuricemia of snow chrysanthemum or snow chrysanthemum extract which have not been found yet.

Inactive Publication Date: 2016-04-27
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no application and research of snow chrysanthemum or snow chrysanthemum extract in the treatment of hyperuricemia

Method used

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  • Novel medicinal application of coreopsis tinctoria
  • Novel medicinal application of coreopsis tinctoria
  • Novel medicinal application of coreopsis tinctoria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 snow chrysanthemum extract

[0024] Get 2000g Snow Chrysanthemum (purchased from Xinjiang Snow Chrysanthemum Biological Technology Co., Ltd.), soak it with 20L of 70v% ethanol at room temperature for 4h, reflux extraction for 60min, filter the extract, add 16L of 70v% ethanol to the filter residue, and heat it at 20°C Extract under reflux for 40 minutes, filter, and combine the two extracts to obtain the snow chrysanthemum extract, which is concentrated to dryness in vacuum to obtain 520g of snow chrysanthemum crude extract (coded as CTE-1), with a yield of 26%.

Embodiment 2

[0025] The preparation of embodiment 2 snow chrysanthemum extract

[0026] The snow chrysanthemum extract was prepared by the same method as in Example 1, and 200 g of the prepared snow chrysanthemum crude extract was taken, dissolved in water, and subjected to chromatography with D101 macroporous adsorption resin. The mass ratio of extract to resin is 1:20. Gradient elution was performed sequentially with water, 30v% ethanol, 60v% ethanol and 95v% ethanol, each gradient eluted 4 times the column volume, and the flow rate was 3 times the column volume / hour. After the elution is completed, the 30v% ethanol eluate, the 60v% ethanol eluate, and the 95v% ethanol eluate are concentrated to dryness to obtain a refined and purified snow chrysanthemum extract.

[0027] Among them, the 30v% ethanol part obtained a total of 62g of refined and purified snow chrysanthemum extract (coded as CT30), the 60v% ethanol part obtained a total of 97g of refined and purified snow chrysanthemum ext...

Embodiment 3

[0029] The preparation of embodiment 3 snow chrysanthemum extract

[0030] Take 2000g Snow Chrysanthemum (purchased from Xinjiang Snow Chrysanthemum Biological Technology Co., Ltd.), soak it with 20L of 50v% ethanol at room temperature for 4h, then reflux extraction at 80°C for 60min, filter the extract, and add 16L of 50v% ethanol to the filter residue , Reflux extraction for 40 minutes, filter, combine two extracts to obtain the snow chrysanthemum extract, vacuum concentrate to dryness, obtain 600g snow chrysanthemum extract (coded as CTE-2), the yield is 30%.

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Abstract

The invention discloses novel medicinal application of coreopsis tinctoria, and particularly relates to application of coreopsis tinctoria extract to preparing medicines for treating hyperuricemia. The novel medicinal application has the advantages that effects of treating the hyperuricemia can be realized by the coreopsis tinctoria extract, the concentration of uric acid in blood can be effectively reduced, and excellent curative effects can be realized for metabolic diseases such as acute gout, chronic gout, gouty arthritis, gout flare, uric acid renal lithiasis and gouty nephropathy which are relevant to the hyperuricemia.

Description

technical field [0001] The invention relates to a new indication of snow chrysanthemum, in particular to a new application of snow chrysanthemum extract in the preparation of medicine for treating hyperuricemia. Background technique [0002] Generally speaking, the state where the uric acid value in the blood exceeds 465 μmol / L is called hyperuricemia. With the change of people's dietary structure and the improvement of living standards, the incidence of hyperuricemia is increasing year by year. According to reports, about 20% of adult males are currently in the state of hyperuricemia. Usually, there is no subjective symptom in the pure state of hyperuricemia, but if the state is left alone for a long time, the urate in the blood will crystallize, and the crystallized urate will be deposited in the joints, subcutaneous tissue, kidneys, etc. Then a series of clinical manifestations such as gout, arthritis, subcutaneous gout stones, kidney stones or gouty nephropathy appear. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P19/06A61P13/04A61P13/12A61P19/02
Inventor 温尧林夏增华陈佳玲徐洁张黎明
Owner CATCH BIO SCI & TECH
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