A multiscale modeling approach for the pathogenesis of cardiac thimthy syndrome

A modeling method and syndrome technology, applied in medical simulation, computer-aided medical procedures, medical informatics, etc., can solve the problems of lack of systematic research, inability to realize micro and macro research, etc.

Active Publication Date: 2018-03-30
哈尔滨文缔拓明科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the current research on the pathogenesis of Timothy syndrome, which presents the characteristics of polarization, and lacks a research method for systematically studying the evolution process of a normal heart from gene CACNA1C mutation, development and transformation to Timothy syndrome arrhythmia. A unified problem of micro- and macro-studies, and a multi-scale modeling method based on the pathogenesis of cardiac Thimthy syndrome

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  • A multiscale modeling approach for the pathogenesis of cardiac thimthy syndrome
  • A multiscale modeling approach for the pathogenesis of cardiac thimthy syndrome
  • A multiscale modeling approach for the pathogenesis of cardiac thimthy syndrome

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specific Embodiment approach 1

[0023] Specific implementation mode one: combine figure 1 To illustrate this embodiment, a modeling method based on the pathogenesis of multi-scale cardiac Thimthy syndrome in this embodiment is specifically prepared according to the following steps:

[0024] Step 1. Using the electrophysiological data and experimental environment information of the Thimthy syndrome ion channel obtained by the patch clamp equipment, the ion channel model of the Thimthy syndrome was established by using Ohm's law, and the differential equation was solved by the forward Euler method to obtain ions with different membrane voltages. The maximum current of the channel, to explore the effect of the mutation of the Thimthy syndrome gene CACNA1C on the current amplitude and area of ​​the ion channel, and to analyze the function of the ion channel;

[0025] Step 2. According to the ion channel model of Thimthy syndrome, the myocardial cell membrane is equivalent to a circuit, the electrophysiological m...

specific Embodiment approach 2

[0033] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the ion channel electrophysiological data and experimental environment information of Thimthy syndrome obtained by the patch clamp equipment in the step one, utilize Ohm's law to establish Thimthy syndrome For the ion channel model, the differential equation is solved by the forward Euler method to obtain the maximum current of the ion channel at different membrane voltages, to explore the effect of the mutation of the Thimthy syndrome gene CACNA1C on the change of the current amplitude and area of ​​the ion channel, and to analyze the function of the ion channel; The specific process is:

[0034] The electrophysiological data of the Cav1.2 channel of Thimthy syndrome patients and the experimental environment information are obtained by patch clamp equipment, wherein the electrophysiological data include the activation curve m ∞(E) , inactivation curve n ∞(E) , time constant...

specific Embodiment approach 3

[0040] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: set up the Thimthy syndrome ion channel model in the described step one; Concrete process is:

[0041] Step 11. According to the temperature coefficient Q 10 =(R 2 / R 1 ) 10 / (T2-T1) Obtain the data from the experimental temperature T1 to the physiological temperature T2 of the cell Cav1.2 channel of the Thimthy syndrome patient acquired by the patch clamp equipment, wherein R1 and R2 are reaction rates, and T2=37 degrees Celsius;

[0042] Step 12: Activate m on Cav1.2 channel ∞(E) curve and inactivation n ∞(E) After the curve is normalized, use m ∞(E) =1 / (1+e (Va-V) / Sa ) to fit the activation curve, using n ∞(E) =1 / (1+e (V-Vina) / Sina ) fits the inactivation curve;

[0043] In the formula: m ∞(E) Obtain the Cav1.2 channel activation curve for the experiment, n ∞(E) To obtain the Cav1.2 channel inactivation curve for the experiment, Va is m ∞(E) =0.5 value,...

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Abstract

The invention relates to a modeling method of heart Thimthy syndrome pathogenesis, in particular to a multiscale based modeling method of heart Thimthy syndrome pathogenesis and aims to solve the problem that uniformity of microscopic and macroscopic study cannot be realized at present. The method comprises steps as follows: 1) a Thimthy syndrome ion channel model is established; 2) a Thimthy syndrome myocardial cell electrophysiological model is established; 3) a Thimthy syndrome cardiac muscle fiber electrophysiological model is established; 4) a heart slice geometric model is established; 5) a Thimthy syndrome myocardial tissue electrophysiological model is established; 6) a heart geometric model is established; 7) a Thimthy syndrome heart electrophysiological model is established; 8) a heart-trunk geometric model of a human body is established; 9) comparison and analysis with a Thimthy syndrome clinic electrocardiogram are performed. The invention is applied to the field of modeling methods of pathogenesis.

Description

technical field [0001] The invention relates to a modeling method based on the pathogenesis of multi-scale cardiac Thimthy syndrome. Background technique [0002] Timothy syndrome is a rare QT syndrome caused by mutations in the gene CACNA1C encoding the Cav1.2 channel. Clinical manifestations include QT interval prolongation, fatal arrhythmia, autism, syndactyly (toe) and multiple organ abnormalities such as the face. Among them, arrhythmia is the main cause of death in patients with Timothy syndrome. Arrhythmia in Timothy syndrome is the result of the interaction of multiple pathological factors, but cardiologists often study the pathogenesis of arrhythmia in Timothy syndrome from a single-scale, single-modal, single-factor and non-systematic perspective, and the developed Anti-arrhythmic β-blockers and calcium channel antagonists in the treatment of Timothy syndrome have been proven to be ineffective, resulting in a high mortality rate of arrhythmia in Timothy syndrome....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/50
CPCG16H50/50
Inventor 王宽全白杰云张恒贵袁永峰李钦策
Owner 哈尔滨文缔拓明科技有限公司
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