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Micro-nano structure hydroxyapatite and preparing method and application thereof

A technology of hydroxyapatite and micro-nano structure, applied in the direction of chemical instruments and methods, applications, phosphorus compounds, etc., can solve the problems of reducing the specific surface area, reducing the reaction efficiency of heavy metals, and easy lodging, and achieves scientific preparation methods and suitable for The effect of large-scale industrial production and reasonable structure

Inactive Publication Date: 2016-04-20
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a slow-release carrier for drugs, this hydroxyapatite nanostructure microsphere has a large drug-loading capacity and obvious slow-release effect, but when it is used to control heavy metal pollution in soil, there are deficiencies. First, , the nanosheets on the surface of the microspheres are extremely prone to lodging during the contact with the soil, which not only greatly reduces the specific surface area, but also greatly reduces the reaction efficiency with heavy metals; secondly, the specific surface area is low, the highest is only 120.6m 2 / g; Again, the preparation method cannot obtain products with higher specific surface area and higher reaction efficiency with heavy metals in soil

Method used

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  • Micro-nano structure hydroxyapatite and preparing method and application thereof
  • Micro-nano structure hydroxyapatite and preparing method and application thereof
  • Micro-nano structure hydroxyapatite and preparing method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0043] The concrete steps of preparation are:

[0044] Step 1, first mix 0.1mol / L calcium solution and 0.6mol / L phosphorus solution according to n(Ca 2+ ): After the molar ratio of 1:1.4 is stirred and mixed, use hydrochloric acid (or nitric acid) to adjust its pH value to 2; wherein, the calcium solution is calcium nitrate tetrahydrate solution, and the phosphorus solution is diammonium hydrogen phosphate solution to obtain a clear solution. After adding chelating agent and urea to the clarified solution, add surfactant to the obtained mixed solution to obtain a precursor solution; wherein, the molar ratio of calcium, chelating agent, urea and surfactant in the precursor solution is 2:1 :600:4, the chelating agent is trisodium citrate, and the surfactant is glycerol.

[0045] In step 2, the precursor solution was placed at 80° C. for 6 hours and then left to age for 24 hours to obtain a reaction solution containing precipitates. Then carry out the treatment of solid-liq...

Embodiment 2

[0047] The concrete steps of preparation are:

[0048] Step 1, first mix 0.3mol / L calcium solution and 0.5mol / L phosphorus solution according to n(Ca 2+ ): After the molar ratio of 1:1.5 is stirred and mixed, use hydrochloric acid (or nitric acid) to adjust its pH value to 2.5; wherein, the calcium solution is calcium nitrate tetrahydrate solution, and the phosphorus solution is diammonium hydrogen phosphate solution to obtain a clear solution. After adding the chelating agent and urea to the clarified liquid, add a surfactant to the obtained mixed liquid to obtain a precursor solution; wherein, the molar ratio of calcium, chelating agent, urea and surfactant in the precursor solution is 15:1 :450:230, the chelating agent is trisodium citrate, and the surfactant is glycerol.

[0049] In step 2, the precursor solution was reacted at 84° C. for 5 hours, and then left to age for 36 hours to obtain a reaction solution containing precipitates. Then carry out the treatment of ...

Embodiment 3

[0051] The concrete steps of preparation are:

[0052] Step 1, first mix 0.5mol / L calcium solution and 0.3mol / L phosphorus solution according to n(Ca 2+ ): The molar ratio is 1:1.67. After stirring and mixing, use hydrochloric acid (or nitric acid) to adjust its pH value to 3; wherein, the calcium solution is calcium nitrate tetrahydrate solution, and the phosphorus solution is diammonium hydrogen phosphate solution to obtain a clear solution. After adding the chelating agent and urea to the clarified liquid, add a surfactant to the obtained mixed liquid to obtain a precursor solution; wherein, the molar ratio of calcium, chelating agent, urea and surfactant in the precursor solution is 30:1 :300:450, the chelating agent is trisodium citrate, and the surfactant is glycerol.

[0053] In step 2, the precursor solution was placed at 88° C. for 4 hours to react, and then left to age for 48 hours to obtain a reaction solution containing precipitates. Then carry out the treatm...

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Abstract

The invention discloses micro-nano structure hydroxyapatite and a preparing method and application thereof. The hydroxyapatite is of a microsphere structure, and the surfaces of the hydroxyapatite microspheres are provided with nanorods. The specific surface area of the hydroxyapatite microspheres with the surfaces provided with the nanorods is larger than or equal to 192 m<2> / g, the spherical diameter of the microspheres ranges from 3 microns to 5 microns, the diameter of the nanorods ranges from 5 nm to 15 nm, and the length of the nanorods ranges from10 nm to 100 nm. The preparing method includes the steps that after a calcium solution and a phosphorus solution are stirred and mixed according to the molar ratio (please see the specification) of 1:(1.4-1.8), adjustment is carried out through hydrochloric acid or nitric acid to obtain clear liquid; after a chelating agent and urea are added into the clear liquid, a surface active agent is added into the obtained mixed liquid to obtain precursor liquid; the precursor liquid is reacted at the temperature of 80-95 DEG C and subjected to standing and aging, and reaction liquid with sediments is obtained; the reaction liquid with the sediments is subjected to solid-liquid separation and washing treatment, and a target product is obtained. The micro-nano structure hydroxyapatite can be widely used for governing and repairing soil polluted by heavy metal.

Description

technical field [0001] The invention relates to a hydroxyapatite, its preparation method and application, in particular to a micro-nano structure hydroxyapatite, its preparation method and application. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) is the main inorganic component in the bones and teeth of vertebrates. It has good biocompatibility, high chemical stability, and does not produce harmful substances after degradation. Nanostructured hydroxyapatite has attracted widespread attention in recent years in the fields of catalyst carriers, bone defect fillings, bioseparation, heavy metal adsorption and separation, especially in drug sustained-release carriers. For example, Chinese invention patent CN102153060B was issued on November 21, 2012. A method for preparing hydroxyapatite nanostructure microspheres announced in Japan. The surface of the hydroxyapatite nanostructured microspheres described in this invention patent is attached with nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32C09K17/06
CPCC01B25/32C01B25/325C01P2002/72C01P2004/03C01P2004/45C01P2004/61C01P2006/12C09K17/06
Inventor 汪国忠董安乐叶新新李虹颖
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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