A kind of external medicine for treating skin eczema and eczema-like dermatitis and preparation method thereof

A technology for skin eczema and external medicine, applied in the field of medicine, can solve problems such as not suitable for children, large skin irritation, and single treatment range, so as to prevent recurrence of rash, increase hydration, and facilitate absorption

Active Publication Date: 2019-01-18
汶上县皮肤病防治站
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the treatment range of ointments is mostly single, often requiring a combination of multiple ointments for treatment, which is troublesome to use, and some medicines are violent in nature and irritating to the skin, so they are not suitable for children

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prepare 13308g of external medicine for the treatment of skin eczema and eczema-like dermatitis, get stearic acid 1500g, glyceryl monostearate 800g, Shihlin 600g, purified water 6200g, glycerin 2520g, triethanolamine 36g, sodium lauryl sulfate 12g, Ethylparaben 16g, miconazole nitrate 140g, chloramphenicol 70g, urea 1400g, triamcinolone acetonide acetate 14g for later use.

[0016] Its preparation steps are as follows:

[0017] (1) First, stearic acid, vaseline, and glyceryl monostearate are mixed together as the oil phase;

[0018] (2) Glycerin, purified water, triethanolamine, sodium lauryl sulfate, and ethylparaben are mixed together for the water phase;

[0019] (3) When the water phase is heated to 78°C-83°C, add urea and stir to dissolve quickly, then add the urea-dissolved water phase at 78°C-83°C to the oil phase at 78°C-83°C under stirring In the middle, and the mixed substance is continuously stirred in one direction until it becomes a milky white semi-solid...

Embodiment 2

[0022] Prepare 16970g of external medicine for the treatment of skin eczema and eczema-like dermatitis, get stearic acid 1800g, glyceryl monostearate 1000g, petrolatum 800g, purified water 8400g, glycerin 3024g, triethanolamine 54g, sodium lauryl sulfate 16g, hydroxyl 20 g of phenethyl ester, 160 g of miconazole nitrate, 80 g of chloramphenicol, 1600 g of urea, and 16 g of triamcinolone acetonide acetate for later use.

[0023] Prepared according to the preparation method of Example 1.

Embodiment 3

[0025] Prepare 18450g of external medicine for the treatment of skin eczema and eczema-like dermatitis, get stearic acid 2000g, glyceryl monostearate 1200g, vaseline 900g, purified water 9000g, glycerin 3276g, triethanolamine 57g, sodium lauryl sulfate 18g, hydroxyl 22 g of phenethyl ester, 170 g of miconazole nitrate, 90 g of chloramphenicol, 1700 g of urea, and 17 g of triamcinolone acetonide acetate for later use.

[0026] Prepared according to the preparation method of Example 1.

[0027] Animal experiment situation of the present invention:

[0028] 1. Experimental materials

[0029] 1.1 Pharmaceutical reagents

[0030] (1) The external medicine for treating skin eczema and eczema-like dermatitis described in the present invention is called Fukang Cream, which is hereinafter referred to as Fukang Cream, and is prepared according to the ratio of Example 1;

[0031] (2), Huaqing Promise Ointment Xinxiang Huaqing Pharmaceutical Co., Ltd.

[0032] (3), Perisone Xi'an Jans...

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PUM

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Abstract

The invention provides an externally-applied drug for treating skin eczema and eczematous dermatitis and a preparation method thereof. The externally-applied drug is prepared from miconazole nitrate, chloramphenicol, urea, triamcinolone acetonide acetate, stearic acid, Vaseline, glycerol monostearate, glycerol, purified water, triethanolamine, lauryl sodium sulfate and ethylparaben. The externally-applied drug can effectively treat and prevent fungus and bacterium single infection and concurrent infection diseases. The externally-applied drug can effectively treat and prevent skin fungus and bacterium single infection and concurrent infection, eczema, eczematous dermatitis and other skin diseases, and the recovery process of various skin diseases is accelerated. Meanwhile, the skin layer rapidly and fully absorbs all the ingredients of the externally-applied drug, all the ingredients are in compatibility in corresponding proportions, the treatment effect of the externally-applied drug prepared through the preparation method is remarkably improved, and the externally-applied drug has the effects of relieving itching, diminishing inflammation, achieving sterilization and eliminating skin surface symptoms, and especially has the obvious effect on various kinds of fungal infection and severe infantile eczema.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an external medicine for treating skin eczema and eczema-like dermatitis and a preparation method thereof. Background technique [0002] Eczema is a common skin disease with complex etiology and severe itching clinically. In the acute phase, it is dominated by papules and has a tendency to exudate. In the chronic phase, it is dominated by lichenification, which is prone to repeated attacks. Eczema-like dermatitis is also a common and frequently-occurring disease in dermatology. Eczematoid dermatitis is an allergic skin disease caused by complex internal and external stimulating factors. It is not only dominated by genetic factors, but also affected by health status and environmental factors. On the basis of infected lesions, the surrounding skin erodes. The patient has a long course of disease, severe pruritus, and strong recurrence, which brings great pain to the patient. Due...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K31/4174A61K31/165A61K47/16A61P17/00A61P31/10A61P31/04
CPCA61K31/165A61K31/4174A61K31/58A61K47/16A61K2300/00
Inventor 张燕信恒舜贾晓晓刘振忠张胜利
Owner 汶上县皮肤病防治站
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