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Application of phillygenin in preparing medicine for treating rheumatoid arthritis

A technology of forsythiaglycoside and arthritis, which is applied in the field of medicine to achieve good therapeutic effects, improve the quality of life, and have definite curative effects

Inactive Publication Date: 2016-04-20
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology shows that the drug is closely related to the immune system, and cytotoxic drugs produce immunosuppressive effects through different channels, which have a great effect on improving the prognosis of rheumatoid arthritis

Method used

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  • Application of phillygenin in preparing medicine for treating rheumatoid arthritis
  • Application of phillygenin in preparing medicine for treating rheumatoid arthritis
  • Application of phillygenin in preparing medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Forsythiagenin Injection

[0018]

[0019] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add forsythiagenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 2

[0020] Example 2 Forsythiagenin Injection

[0021]

[0022] Preparation process: mix the prescribed amount of PEG-400 with ethanol, add forsythiaside, stir to dissolve, add 0.9% sodium chloride solution to 10000ml, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 3

[0023] Example 3 Forsythiagenin Injection

[0024]

[0025] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add forsythiagenin, stir to dissolve, add water for injection to 10000ml, stir evenly, add 0.5% activated carbon for needles, stir for decarbonization, and then divide and pack.

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PUM

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Abstract

The invention relates to medicinal application of phillygenin, in particular to application of the phillygenin in preparing a medicine for treating arthritis, belonging to the field of medicine. The invention aims at providing an arthritis treating medicine, which takes the phillygenin as a major active ingredient; the medicine, when used for treating rheumatoid arthritis or rheumatic arthritis, has the characteristics of concrete curative effect and low adverse reaction; animal experiments show that the medicine can greatly improve the pain threshold of a rat with the arthritis and can take effects on significantly lowering a foot swelling value and reducing an inflammatory factor TNF-alpha; and the phillygenin is suitable for preparing medicines for the clinical treatment of the arthritis.

Description

technical field [0001] The invention relates to a medical use of forsythiagenin, in particular to the use of forsythiagenin in the preparation of medicines for treating rheumatoid arthritis, and belongs to the field of medicine. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, belonging to autoimmune inflammatory diseases . The disease is prone to occur in small joints such as hands, wrists, and feet, and is easy to recur, and is symmetrically distributed. In the early stage of the disease, joints are red, swollen, hot, painful, and dysfunctional. In the late stage, the joints may appear stiff and deformed in varying degrees, accompanied by atrophy of bones and skeletal muscles, and are easily disabled. From the perspective of pathological changes, rheumatoid arthritis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P19/02A61P29/00
Inventor 赵志全宋洪运张永霞李晓梅曹玉早
Owner SHANDONG NEWTIME PHARMA
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