Platinum(iv) Anticancer Compounds Using Dihydrogen Phosphate as Axial Ligand
A dihydrogen phosphate and compound technology, applied in the field of biopharmaceuticals, can solve problems such as poor water solubility, poor anticancer activity, and failure to be approved for marketing, and achieves the effects of good selectivity, high anticancer activity, and good clinical application prospects.
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[0041] (1) The synthetic method of Pt (IV) anticancer compound PPt1 of the present invention
[0042] Weigh 8.40g (28mmol) cisplatin, add 250ml of water, stir, heat to 60°C, add 30wt% H 2 o 2 420ml, continue to stir and react at 60°C for 4 hours, cool to room temperature, precipitate a light yellow product, filter, wash with ice water, dry, and recrystallize in water to obtain cis, trans, cis-[ Pt(IV)(NH 3 ) 2 (OH) 2 Cl 2 ]5.8g, the yield is about 62%.
[0043] Accurately weigh 2.061g (6.17mmol) cis, trans, cis-[Pt(IV)(NH 3 ) 2 (OH) 2 Cl 2 ], add 0.678 grams of 85% phosphoric acid solution (5.88mmol, be equivalent to 95% of stoichiometry), after stirring and mixing, add 50ml of water stirring reaction again at 60 ℃ and after concentrating under reduced pressure to near dryness, add 100ml of Stir to dissolve in water, cool to room temperature, filter out unreacted cis, trans, cis-[Pt(IV)(NH 3 ) 2 (OH) 2 Cl 2 ], the filtrate was freeze-dried to obtain light yellow ...
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