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Scattering medium-penetrating laser speckle flow speed detection method and device thereof

A laser speckle and flow velocity detection technology, applied in the field of optical imaging, can solve the problems of limited sampling depth, inability to fundamentally eliminate scattering media, multiple light scattering, etc., and achieve the effect of real-time flow velocity detection

Active Publication Date: 2016-03-30
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

However, the sampling depth of this technology is limited, and it mainly detects blood flow information on the surface of biological tissues
The main reason is that the incident laser is disturbed by the biological tissue due to the scattering effect of the tissue, causing multiple scattering of the light, which seriously affects the information transmission and imaging quality, and cannot extract the flow velocity information of the deep tissue.
Although some studies have combined laser speckle blood flow imaging with orthogonal polarization methods to reduce specular reflection, or used optical transparent agents to reduce tissue light scattering, which has improved the sampling depth of blood flow signals to a certain extent, but the improvement not high
It cannot fundamentally eliminate the influence of the scattering medium, and realize the flow velocity imaging through the scattering medium

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  • Scattering medium-penetrating laser speckle flow speed detection method and device thereof

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Embodiment Construction

[0033] The present invention proposes a laser speckle flow velocity detection device through a scattering medium, which adopts the following figure 1 The imaging device shown is composed of the following components: a laser 1 sequentially arranged along the propagation direction of the optical path, a neutral density filter 2, a collimating beam expander system (lens one 3 and lens two 4), a polarizer 5, and an object plane 6. The object plane is provided with a pinhole as a point object or a diaphragm and a moving scattering object are placed at the object plane, an optical diffusion sheet 7, 4f system (lens three 8 and lens four 11) as a scattering medium, a light baffle 9, A beam splitter 10, a spatial light modulator (SLM) 12, a lens 13 and a CCD or a CMOS camera 14; the beam emitted by the laser 1 passes through a collimated beam expander system, irradiates the pinhole placed on the object plane and passes through the pinhole placed behind it. The diffuser, the rear surfa...

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Abstract

The invention discloses a scattering medium-penetrating laser speckle flow speed detection method and a device thereof. The scattering medium-penetrating laser speckle flow speed detection method is characterized in that based on the optical memory effect of the scattering medium, the spatial light modulator can be used for the compensation matching of the random phases generated by the light waves passing through the scattering mediums, and by combining with the laser speckle comparing and analyzing method, the scattering medium-penetrating flow speed imaging can be realized. The device provided by the invention is characterized in that a light beam transmitted by a laser device can be used to illuminate the object plane and the scattering medium after passing through a collimating and beam expanding system. The rear surface of the scattering medium can be imaged on the spatial light modulator by adopting a 4f system, and the light modulated by the spatial light modulator can be reflected to a light splitting sheet along an optical path, and then can be received by a CCD camera or a CMOS camera via a lens five. The scatheless, non-contact, and scattering medium-penetrating real-time wide field flow speed imaging can be realized.

Description

technical field [0001] The invention belongs to the field of optical imaging, and relates to an optical imaging technology for passing through a scattering medium, in particular to a method and device for detecting flow velocity through a scattering medium based on a wavefront modulation technology and a laser speckle contrast analysis method. Background technique [0002] Laser speckle blood flow imaging technology is a wide-field blood flow imaging technology with high temporal and spatial resolution and easy control of the imaging range. It is used in intraoperative detection, research on neurovascular coupling mechanisms, and drug evaluation. However, the sampling depth of this technology is limited, and it mainly detects blood flow information on the surface of biological tissues. The main reason is that the incident laser is disturbed by the biological tissue due to the scattering effect of the tissue, causing multiple scattering of the light, which seriously affects t...

Claims

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Application Information

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IPC IPC(8): G01P5/26A61B5/026
CPCA61B5/0059A61B5/026G01P5/26
Inventor 李鹏程骆清铭李阳阳陆锦玲
Owner HUAZHONG UNIV OF SCI & TECH
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