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Preparing method of multi-branch colloidal gold nano particles with controllable grain diameter and high light absorbing intensity

A colloidal gold, high light absorption technology, applied in the development of precious metal nanoparticles, can solve the problems of waste of manpower, material and financial resources, weak light absorption intensity of solution, low concentration of gold particles, etc., and achieves short reaction time, good monodispersity, The effect of high light absorption

Active Publication Date: 2016-03-30
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the concentration of gold particles in the multi-dendritic colloidal gold solution synthesized by it is relatively low, and the light absorption intensity of the solution itself is very weak. To increase its absorbance intensity, the solution pretreatment process not only increases the workload, but also greatly wastes manpower, material resources and financial resources.

Method used

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  • Preparing method of multi-branch colloidal gold nano particles with controllable grain diameter and high light absorbing intensity
  • Preparing method of multi-branch colloidal gold nano particles with controllable grain diameter and high light absorbing intensity
  • Preparing method of multi-branch colloidal gold nano particles with controllable grain diameter and high light absorbing intensity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 The particle size is 33 ± 3nm, the preparation of high absorbing intensity polydendric colloidal gold nanoparticles

[0028] Using spherical colloidal gold nanoparticles with a particle size of 18±2nm as seeds:

[0029] (1) Synthesis of spherical colloidal gold seed solution (spherical colloidal gold nanoparticles): using the classic trisodium citrate reduction method, accurately pipette 1 mL of 1% HAuCl 4 Put the solution into a conical flask filled with 99mL ultrapure water, stir slowly on a magnetic stirrer and heat to boiling, then speed up the speed and quickly add 2.7mL1% Na at one time 3 C 6 h 5 o 7 Solution, continue to boil for 15min, until the color of the solution turns wine red and no longer changes, stop heating, stir at a constant speed and cool to room temperature, to obtain a spherical colloidal gold seed solution ( image 3 A). Such as figure 2 , the maximum surface plasmon resonance absorption wavelength was determined to be 520nm, the...

Embodiment 2

[0033] Example 2 Construction of Immunochromatographic Test Strips Based on High Absorbance Intensity and Low Absorbance Intensity Polydendrified Colloidal Gold Nanoparticles

[0034] Ochratoxin (OTA) was used as the analyte in a competitive inhibition mode. The test strip is composed of a sample pad, a binding pad, a nitrocellulose membrane, absorbent paper and a PVC bottom plate. The nitrocellulose membrane is coated with an ochratoxin antigen and a donkey anti-mouse secondary antibody as the detection line (T) and quality respectively. Control line (C):

[0035] (1) Particle size is 33 ± 3nm, high absorbing intensity polydendrite colloidal gold nanoparticle immunochromatographic test strip construction: be 33 ± 3nm with particle diameter, high absorbing intensity polydendric colloidal gold nanoparticle (take implementation The polydendritic colloidal gold solution with high absorbing intensity obtained in Example 1, without concentration treatment) is used as a labeling ma...

Embodiment 3

[0040] Example 3 The particle size is 68 ± 2nm, and the preparation of high absorbing intensity multi-dendrite colloidal gold nanoparticles

[0041] Using spherical colloidal gold nanoparticles with a particle size of 18±2nm as seeds:

[0042] (1) Synthesis of spherical colloidal gold seed solution (spherical colloidal gold nanoparticles): using the classic trisodium citrate reduction method, accurately pipette 1 mL of 1% HAuCl 4 Put the solution into a conical flask filled with 99mL ultrapure water, stir slowly on a magnetic stirrer and heat to boiling, then speed up the speed and quickly add 2.7mL1% Na at one time 3 C 6 h5 o 7 Solution, continue to boil for 15min, until the color of the solution turns wine red and no longer changes, stop heating, stir at a constant speed and cool to room temperature, to obtain a spherical colloidal gold seed solution ( image 3 A). Such as figure 2 , the maximum surface plasmon resonance absorption wavelength was determined to be 520nm...

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Abstract

The invention relates to the field of nano material development and application, and discloses a method for synthesizing multi-branch colloidal gold nano particles different in grain diameter and high in light absorbing intensity through colloidal gold seed mediation growth. The method comprises the steps that firstly, a conventional trisodium citrate reduction method is adopted, Au3+ in chloroauric acid molecules is reduced into Au0, and ball-shaped colloidal gold seeds are obtained; then, the colloidal gold seeds are added into a growth solution, wherein the growth solution mainly comprises ultrapure water, chloroauric acid, trisodium citrate and other solutions; a magnetic stirring device is used for performing slow stirring, after the solution is evenly mixed, the solution is heated to 50 DEG C, and the rotating speed is increased at the time; and meanwhile a sufficient hydroquinone solution is added at a time, the temperature of the mixed solution is maintained at 50 DEG C, heating is stopped after the reaction is continuously carried out for 10 min, and a multi-branch colloidal gold solution high in light absorbing intensity can be obtained through cooling to the room temperature. The method has the beneficial effects of being easy to operate, simple in procedure, rapid in reaction, good in controllability, high in repeatability and the like.

Description

technical field [0001] The invention relates to the development of noble metal nanoparticles in the field of nanomaterial development and application, in particular to a method for synthesizing multi-branched colloidal gold nanoparticles with different particle sizes and high light absorption intensity through colloidal gold seed-mediated growth. Background technique [0002] Colloidal gold (colloidgold), also known as nanogold (nanogold), refers to a gold sol with a dispersed phase particle diameter between 1-150nm, which belongs to a heterogeneous heterogeneous system. Colloidal gold particles consist of a basic gold core (Au atom) surrounded by a double ion layer, such as figure 1 As shown, the inner layer of negative ions is closely connected to the surface of the gold core, and the outer layer of ions is dispersed in the colloidal solution to maintain the suspension state of the colloidal gold free in the sol. The color of colloidal gold solution depends on the particl...

Claims

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Application Information

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IPC IPC(8): B22F9/24G01N33/53
Inventor 熊勇华徐鹏江湖赖卫华李娟
Owner NANCHANG UNIV
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