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Production method of Shuganning Preparation

A production method and preparation technology, which is applied in the production field of Shuganning preparations, can solve the problems of affecting the curative effect of medicines, low polysaccharide content, and difficult detection, and achieve the effects of improving drug efficacy, high content of Ganoderma lucidum polysaccharides, and easy dissolution

Active Publication Date: 2016-03-23
GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventor found in the course of research that Ganoderma lucidum polysaccharides in Ganoderma lucidum polysaccharides are not easy to detect in the Shuganning injection prepared by using the existing extraction process, and the polysaccharides in Ganoderma lucidum are the main active ingredients of Ganoderma lucidum , but the polysaccharide content of the ganoderma lucidum extract prepared by the prior art is not high, which affects the curative effect of the drug

Method used

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  • Production method of Shuganning Preparation
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  • Production method of Shuganning Preparation

Examples

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Effect test

Embodiment 1

[0077] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0078] The production method of Shuganning injection: add water for injection to baicalin, make it suspended, add 10% sodium hydroxide solution to dissolve; add capillary extract, gardenia extract, isatis root extract and Ganoderma lucidum extract Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0079] Extraction process of Ganoderma lucidum extract:

[0080] 1. Take Ganoderma lucidum, wash it, add 3 times the amount of ethanol with a concentration of 85%, soak it at 80°C for 3 hours, and obtain product A;

[0081] 2. Make product A into a slurry, add 0.2 times of 0.02mol / l citric acid solution and 0.1 times of 1-2mol / l HCL solution to the ...

Embodiment 2

[0089] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0090] The production method of Shuganning injection: add water for injection to baicalin, make it suspended, add 10% sodium hydroxide solution to dissolve; add capillary extract, gardenia extract, isatis root extract and Ganoderma lucidum extract Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0091] Extraction process of Ganoderma lucidum extract:

[0092] 1. Take Ganoderma lucidum, wash it, add 4 times the amount of ethanol with a concentration of 90%, and soak it at 75-85°C for 4 hours to obtain product A;

[0093] 2. Beat product A into a slurry, add 0.3 times the amount of 00.03mol / l citric acid solution and 0.15 times the amount of ...

Embodiment 3

[0101] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0102] The production method of Shuganning injection: add water for injection to baicalin, make it suspended, add 10% sodium hydroxide solution to dissolve; add capillary extract, gardenia extract, isatis root extract and Ganoderma lucidum extract Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0103] Extraction process of Ganoderma lucidum extract:

[0104] 1. Take Ganoderma lucidum, wash it, add 2-4 times the amount of ethanol with a concentration of 80-90%, soak it at 75-85°C for 2-4 hours, and get A product;

[0105] 2. Make product A into a slurry, add 0.1 times the amount of 0.01mol / l citric acid solution and 0.05 times the amount of...

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Abstract

The invention discloses a production method of a Shuganning preparation. The Shuganning preparation is mainly prepared from a capillary artemisia extract, a gardenia extract, baicalin, a radix isatidis extract and a lucid ganoderma extract. According to the production method disclosed by the invention, a method for extracting the lucid ganoderma extract is improved, and especially the concrete process and parameters of the method are improved, such that polysaccharose in lucid ganoderma is easily detected and the content of the detected polysaccharose in the lucid ganoderma is high. The drug effect of the Shuganning preparation can be effectively improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation method of Shuganning preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Shuganning injection is a liver-protecting drug, mainly made of capillary extract, gardenia extract, baicalin, isatis root extract and ganoderma lucidum extract. It has the effects of clearing away heat and detoxification, promoting dampness and reducing jaundice, nourishing qi and strengthening the body, and protecting the liver. It is used for damp-heat jaundice, yellow eyes and eyes, fullness of breast ribs, naus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/08A61P1/16A61K31/7048
Inventor 何峰张昀潘金成彭相印
Owner GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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