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Compound preparation containing vonoprazan and non-steroidal anti-inflammatory drugs

A technology of non-steroidal anti-inflammatory drugs and compound preparations, applied in the field of medicine

Inactive Publication Date: 2016-03-23
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The problem to be solved by the present invention is: ① To make the non-steroidal anti-inflammatory drug form a stable weakly alkaline environment in the stomach, it is necessary to ensure that the non-steroidal anti-inflammatory drug and vonoprazan are used in proportion; ② non-steroidal anti-inflammatory drug There is no direct contact between steroidal anti-inflammatory drugs and Vonorazan; ③The preparation technology must be simple and easy to implement, and should not cause a burden on the enterprise, and then spread the cost to the patients

Method used

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  • Compound preparation containing vonoprazan and non-steroidal anti-inflammatory drugs
  • Compound preparation containing vonoprazan and non-steroidal anti-inflammatory drugs
  • Compound preparation containing vonoprazan and non-steroidal anti-inflammatory drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0013]

[0014]

[0015] Preparation method: Mix the prescribed amount of aspirin, tartaric acid and 85g lactose, wet granulate with 10% starch slurry, boil and dry; mix the aspirin granules with 8g microcrystalline cellulose and 7g talcum powder, press into tablets, and wrap the isolation layer Mix Vonorazan, aspartame 0.1g, sodium carboxymethylcellulose 5g and lactose 5g, add water to moisten, wrap around the tablet core, and dry to obtain.

Embodiment 2

[0017] Indomethacin 75mg, Vonorazan 10mg;

[0018] Indomethacin

[0019] Preparation method: Mix the prescription amount of indomethacin, tartaric acid and 90g lactose, wet granulate with 10% starch slurry, and boil and dry; mix indomethacin granules with 8g low-substituted hydroxypropyl cellulose and 7g talcum powder Mix evenly, compress into tablets, and wrap the isolation layer; mix Vonorazan, 0.1g of aspartame, 5g of sodium carboxymethylcellulose and 6g of lactose, add water to moisten, wrap around the tablet core, and dry to obtain .

Embodiment 3

[0021] Ketoprofen 25mg, Wonorazan 10mg;

[0022] Ketoprofen

[0023] Preparation method: mix ketoprofen, tartaric acid and 100g lactose in the prescribed amount, wet granulate with 10% starch slurry, boil and dry; mix ketoprofen granules with 38g microcrystalline cellulose and 7g talcum powder, and compress into tablets , wrapped with an isolation layer; mix Vonorazan, 0.1g of aspartame, 5g of carboxymethylcellulose sodium and 25g of lactose, moisten with water, wrap around the tablet core, and dry to obtain.

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PUM

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Abstract

The invention provides a compound preparation containing vonoprazan and non-steroidal anti-inflammatory drugs. The compound preparation is characterized by being an inner-outer multi-layer preparation prepared from the vonoprazan and one or more than one non-steroidal anti-inflammatory drugs; an isolation layer is arranged between the inner-layer drug and the outer-layer drug to prevent contact of the vonoprazan and the non-steroidal anti-inflammatory drugs. The vonoprazan can inhibit gastric acid secretion, improve the clinical symptoms such as gastric acid increasing and epigastrium pain, reduce the pessimal stimulation of the non-steroidal anti-inflammatory drugs such as aspirin to the stomach and significantly reduce the occurrence rate of gastric mucosal erosion and anabrosis, and therefore the protective effect on the stomach is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound preparation prepared by a specific process from vonoprazan, non-steroidal anti-inflammatory drugs and pharmaceutical excipients. Background technique [0002] Vonorazan was developed by Japan's Takeda Pharmaceutical Co., Ltd. and is a new type of gastric acid secretion inhibitor. The specific structural formula is as follows: [0003] [0004] In the final step of gastric acid secretion from parietal cells, it can competitively inhibit the combination of potassium ions and hydrogen-potassium ATPase, and thus is classified as a potassium-competitive acid inhibitor (P-CAB). Vonorazan has a strong and long-lasting inhibitory effect on gastric acid secretion, and can inhibit the recurrence of gastric ulcer or duodenal ulcer caused by low-dose aspirin and non-steroidal anti-inflammatory drugs. [0005] Currently, proton pump inhibitors (PPIs) are widely prescribed for the first-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4439A61K45/06A61K31/616A61P7/02A61K31/192A61K31/405
CPCA61K45/06A61K9/209A61K31/192A61K31/405A61K31/4439A61K31/616
Inventor 陈勇刘露王晓丹
Owner FUKANGREN BIO PHARMA
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