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Focused ultrasound apparatus and methods of use

A focused ultrasound and ultrasound technology, applied in ultrasound therapy, ultrasound/sonic/infrasound diagnosis, and the structure of ultrasound/sonic/infrasound diagnostic equipment, etc. The effect of the risk of infection

Active Publication Date: 2016-03-09
UNIV OF WASHINGTON CENT FOR COMMERICIALIZATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this technique is less invasive than open repair, the device may implant bacteria in the urine and lead to UTI
In addition, there are concerns about the use of general anesthesia in children, especially newborns

Method used

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  • Focused ultrasound apparatus and methods of use
  • Focused ultrasound apparatus and methods of use
  • Focused ultrasound apparatus and methods of use

Examples

Experimental program
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Effect test

Embodiment 1

[0086] METHODS: Fresh bovine bladders were used to create two models of the ureteral hernia wall. The first is a herpes model created by injecting 1-2 mL of stained standard saline into the submucosa. The second is the exfoliated mucosa that separates from the muscle layer. The tissue is located in a degassed water bath, and the target layer is brought into focus with a 1 MHz ultrasound transducer. Pulsed focused ultrasound is applied to create visible holes in the wall. The pulse amplitudes employed were similar to those applied for extracorporeal shock wave lithotripsy, with a peak positive pressure p+=100-120 MPa and a peak negative pressure of 17-20 MPa. Pulse duration and pulse rate were varied between different exposures. Record the puncture time and puncture size. The use of ultrasound imaging as targeting and processing feedback has also been explored.

[0087] RESULTS: Focused ultrasound produced erosion and perforation of the wall in a time period between 50-300...

Embodiment 2

[0090] In this example, a tissue model of the ureterocele wall was used to evaluate the feasibility of using tissue abolition under ultrasound image guidance to produce mechanical punctures.

[0091] Materials and methods: Freshly resected bovine bladder tissue was used to model the ureteral hernia wall. Bladders were harvested and kept in degassed phosphate buffered saline until use (less than 12 hours from resection). The bladder was divided into 5x5 cm segments. The mucosa and submucosa are stripped from the underlying muscle and adventitia to form a membrane with a thickness of 0.5-1 mm. Mucosa is placed over the circular opening of a polypropylene chamber containing stained saline. The membrane is secured around the container by straps such that the membrane seals the fluid within the chamber without exerting tension on the membrane, other than that caused by the sample's own weight. This model provides an endpoint for judging a puncture when stained saline is observed...

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Abstract

Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of the filing date of US Provisional Patent Application Serial No. 61 / 806,295, filed March 28, 2013, which is hereby incorporated by reference in its entirety. [0003] Statement of Government Interest [0004] This invention was made with government support 2T32DK007779-11A1 and 2R01EB007643-05 awarded by the National Institutes of Health (NIH). The US Government has certain rights in this invention. Background technique [0005] Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this application and are not admitted to be prior art by inclusion in this section. [0006] A ureterocele is a thin cystic eversion of the ureter leading to the bladder beyond the ureterovesical junction and is associated with febrile urinary tract infection, urinary retention, and renal obstruction or injury. Ureteral hernias are usually detected...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/02
CPCA61N7/02A61N2007/006A61N2007/0065A61N2007/0078A61N2007/0086A61B8/44A61B8/4444A61B2090/3784A61B8/0866A61N7/00
Inventor A·马克斯韦尔R·赫斯T·莱迪威P·卡萨勒M·贝利
Owner UNIV OF WASHINGTON CENT FOR COMMERICIALIZATION
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