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Cell cultivation model for artificial cornea reconstruction

An artificial cornea and cell technology, applied in the field of medical research, can solve the problems of transplantation failure, cell purity and density not meeting the requirements, etc., and achieve the effect of small cell interference, difficult displacement, and guaranteed density and purity

Inactive Publication Date: 2016-02-17
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if excellent seed cells are used, if the cell purity and density cannot meet the requirements during the planting process, it will lead to the failure of transplantation

Method used

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  • Cell cultivation model for artificial cornea reconstruction
  • Cell cultivation model for artificial cornea reconstruction
  • Cell cultivation model for artificial cornea reconstruction

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Embodiment Construction

[0015] In order to facilitate the understanding of the working principle of the present invention, the following description will be made in conjunction with the accompanying drawings and embodiments.

[0016] refer to figure 1 , 2 As shown, the cell implantation model 1 for artificial corneal reconstruction of the present invention mainly includes a carrier bracket 10 and a supporting shell 20, wherein:

[0017] The carrier bracket 10 is used for cell planting, which includes a first planting surface 11 and a second planting surface 12, and a closed ring-shaped fixed area 13 is provided on the outer edge of the first planting surface 11 and the second planting surface 12, as the present In a preferred embodiment of the invention, the closed annular fixing area 13 is designed to have a width of 1-2mm.

[0018] The support shell 20 is used to support the carrier bracket 10, which includes a first tube body 21, a second tube body 22 and a third tube body 23, and the above-ment...

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Abstract

The invention discloses a cell cultivation model for artificial cornea reconstruction. The cell cultivation model comprises a carrier bracket for cell cultivation and a supporting shell for supporting the carrier bracket. According to the designed model, firstly the carrier bracket is fixed to the supporting shell made of silica gel, then the carrier bracket is placed in a culture dish for cell cultivation, the supporting shell has a good supporting function on the carrier bracket, especially a thin-layer bracket, and the carrier bracket can be not prone to displacement and curl in the cultivation process.

Description

technical field [0001] The invention relates to the technical field of medical research, in particular to a model for planting corneal endothelial cells and / or corneal epithelial cells on any carrier support for tissue engineering artificial cornea reconstruction Background technique [0002] The cornea is a transparent tissue located at the front of the eye, consisting of an epithelial cell layer, a stroma layer, and an endothelial cell layer. Corneal epithelial cells (corneal epithelial cells) are vulnerable to microbial invasion, mechanical trauma, chemical burns and thermal burns due to their special location and structure. Corneal limbal stem cells (corneal limbal epithelial cells) are the source of corneal epithelial cell renewal and regeneration. Many serious ocular surface diseases, such as Stevens-Johnson syndrome and ocular cicatricial pemphigoid, eye infection and trauma, etc. will lead to the lack of limbal stem cells, which will lead to the loss of regeneration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00
CPCC12M21/08C12M23/48
Inventor 张志华刘堃刘海芸许迅张超
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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