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Industrial production method for 2, 6-difluorobenzaldehyde

A technology of difluorobenzaldehyde and production method, which is applied in chemical instruments and methods, separation/purification of carbonyl compounds, organic chemistry, etc., can solve problems such as inability to meet market demand, difficulty in production control, and low yield

Inactive Publication Date: 2016-02-10
YANGZHOU TIANCHEN FINE CHEM
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] The existing synthetic methods of 2,6-difluorobenzaldehyde include: electrochemical method, chemical method, fluorination method, etc., but the defects in the production of the above various 2,6-difluorobenzaldehyde are: difficult production control, Low output, high cost, not suitable for market demand

Method used

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Embodiment Construction

[0019] 1. Material preparation: Weigh 400kg of sulfolane, 200kg of anhydrous potassium fluoride, 20kg of tetrabutylammonium chloride, 50kg of toluene and 100kg of 2,6-dichlorobenzaldehyde respectively.

[0020] 2. Production steps

[0021] 1. In the reaction kettle, mix sulfolane with toluene, then heat up to 110-130℃, remove the water in the raw material, and then steam the toluene to obtain pure sulfolane.

[0022] 2. Add anhydrous potassium fluoride, tetrabutylammonium chloride and 2,6-dichlorobenzaldehyde to the fluorination kettle, drive out the oxygen-containing air in the fluorination kettle with nitrogen, and after sealing, put it into the fluorination kettle. Steam is introduced into the jacket, and the temperature of the feed liquid in the fluorination kettle is raised to 150-155°C to carry out the fluorination reaction.

[0023] 3. Under the vacuum condition of -0.098MPa, distill the mixture after the fluorination reaction, and distill the mixture of 2,6-difluorobe...

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PUM

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Abstract

The invention discloses an industrial production method for 2, 6-difluorobenzaldehyde and relates to the technical field of production of pesticide, medicine and liquid crystal raw materials. 2, 6-dichlorobenzaldehyde serves as the raw material, tetrabutylammonium chloride serves as a catalyst, sulfolane and methylbenzene serve as media, and potassium fluoride halogens are synthesized into 2, 6-difluorobenzaldehyde through exchange and fluoridation. According to the method, a fluoridation reaction is conducted under the water-free and oxygen-free condition, and by means of the method, an industrial product which is high in quality and synthesis conversion rate can be obtained.

Description

technical field [0001] The invention relates to the technical field of production of pesticides, medicines and liquid crystal raw materials, in particular to the technical field of production of 2,6-difluorobenzaldehyde. Background technique [0002] 2,6-Difluorobenzaldehyde, molecular formula: C 7 H 4 F 2 0, the molecular weight is 142.10, and the finished product is light yellow liquid or solid. 2,6-Difluorobenzaldehyde is an important organic chemical raw material. It is an intermediate of medicine, pesticide and liquid crystal material. It can be used to synthesize new antiviral drugs and benzoylurea insecticides, and can also synthesize fluorine Substituted dodecyl porphyrins. [0003] The current synthesis methods of 2,6-difluorobenzaldehyde include: electrochemical method, chemical method, fluorination method, etc., but the above-mentioned defects in the production of various 2,6-difluorobenzaldehyde are: production control is difficult, The output is low and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/63C07C45/82C07C47/55
CPCC07C45/63C07C45/82C07C47/55
Inventor 陈国云王晨潘明生刘润兴张小凤沈忠诚罗瑞江涵周卫华
Owner YANGZHOU TIANCHEN FINE CHEM
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