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Paederia scandens extract and applications thereof

A technology of chia japonica and extract, applied in the field of veterinary medicine, can solve problems such as drug residues, and achieve the effects of ensuring normality, ensuring healthy growth, and reducing the use of

Active Publication Date: 2016-02-03
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some stable antibiotics are excreted into the environment, resulting in drug residues in the environment

Method used

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  • Paederia scandens extract and applications thereof
  • Paederia scandens extract and applications thereof
  • Paederia scandens extract and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An extract of vine vine, containing 98.3% iridoid glycosides, prepared by the following method:

[0033] (1) Take the medicinal material of vine vine, add 10 times the amount of 75% (v / v) ethanol to reflux for extraction for 2 hours, filter the extract, repeat the above extraction process 3 times with the dregs, combine the extract, concentrate under reduced pressure at 60 ° C, until nothing Alcoholic taste, add 5 times the amount of medicinal materials in distilled water to dissolve, centrifuge to obtain supernatant;

[0034] (2) D101 macroporous adsorption resin on the supernatant, the ratio of medicinal material to resin is 300ml of D101 macroporous resin pretreated by swelling with absolute ethanol for every 1kg of medicinal material, the resin column diameter-to-height ratio is 1:8, and the sample is loaded The flow rate is 2.0BV / h, and the elution flow rate is 6BV / h;

[0035] (3) After loading the sample, first elute the resin column 2BV with distilled water, dis...

Embodiment 2

[0037] An extract of vine vine, containing 89.2% iridoid glycosides, prepared by the following method:

[0038] (1) Take the medicinal material of vine vine, add 12 times the amount of 75% (v / v) ethanol to extract under reflux for 3 hours, filter the extract, repeat the above extraction process twice with the dregs, combine the extract, concentrate under reduced pressure, until there is no alcohol smell , add 2 times the amount of medicinal materials in distilled water to dissolve, centrifuge to obtain supernatant;

[0039] (2) D101 macroporous adsorption resin on the supernatant, the ratio of medicinal material to resin is 400ml of D101 macroporous resin pretreated by swelling with absolute ethanol for every 1kg of medicinal material, the resin column diameter-to-height ratio is 1:10, and the sample is loaded The flow rate is 1.5BV / h, and the elution flow rate is 5BV / h;

[0040] (3) After loading the sample, first elute the resin column 2BV with distilled water, discard the ...

Embodiment 3

[0042] An extract of vine vine, containing 76.9% iridoid glycosides, prepared by the following method:

[0043] (1) Take the medicinal material of vine vine, add 8 times the amount of 75% (v / v) ethanol to reflux for extraction for 1 hour, filter the extract, repeat the above extraction process 3 times with the dregs, combine the extract, concentrate under reduced pressure, until there is no alcohol smell , add 6 times the amount of medicinal material in distilled water to dissolve, centrifuge to obtain supernatant;

[0044] (2) D101 macroporous adsorption resin on the supernatant, the ratio of medicinal material to resin is 200ml of D101 macroporous resin pretreated by swelling with absolute ethanol for every 1kg of medicinal material, the ratio of resin column diameter to height is 1:12, and the sample is loaded The flow rate is 1.0BV / h, and the elution flow rate is 4BV / h;

[0045] (3) After loading the sample, first elute the resin column 2BV with distilled water, discard t...

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Abstract

The present invention provides a paederia scandens extract and applications thereof. According to the present invention, the paederia scandens extract provides important application values in treatment of food retention, diarrhea, dyspepsia and other gastrointestinal tract diseases; and the compound traditional Chinese medicine comprising the paederia scandens extract, dried ginger, radix aconiti lateralis preparata, alisma orientalis and glucose oxidase provides good market prospects in the fields of inhibition and killing of pathogenic microorganisms, treatments of food retention, diarrhea, dyspepsia and other gastrointestinal tract diseases, promotion of animal growth, improvement of feed conversion rate, and the like.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to an extract of vine vine and its application. Background technique [0002] With the development of intensive animal husbandry, livestock diseases are becoming more and more complex, and the use of veterinary drugs and antibiotic feed additives is also increasing. Some antibiotics with stable properties are excreted into the environment, resulting in drug residues in the environment. These residual drugs can be directly accumulated in the human body through livestock and poultry products or released into other plants through the environment, and finally gather in the human body in various ways, leading to chronic toxicity in the human body and changes in the drug resistance of normal flora in the body. Natural plant drugs have a unique structure, are not easy to produce drug resistance, can be degraded in the environment, do not cause irreversible damage to the environment, are...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K38/44A61P1/14A61P1/12A61P31/04
Inventor 杨雪朱士江王宇鹏董泽武侯建军程雪娇焦晓军王勇姜慧新甄盼盼王猛崔志刚余贵菊张立会姜淋洁李丽琴于小婷范庆增李玲
Owner TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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