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Osteoporosis diagnosis marker

A technology for osteoporosis and products, which is applied in the application field of products, can solve the problems that patients with osteoporosis cannot be screened, and achieve the effect of early diagnosis, better genetic diagnosis and lower mortality

Inactive Publication Date: 2016-01-20
BEIJING MEDINTELL BIOMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The objects of auxiliary examination are generally patients with advanced osteoporosis, and cannot be used for the screening of patients with early osteoporosis

Method used

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  • Osteoporosis diagnosis marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Screening of genes differentially expressed in patients with osteoporosis and normal people

[0050] 1. Research object:

[0051] Osteoporosis group: randomly select 10 patients with primary osteoporosis admitted to the orthopedics department of the hospital, 5 males and 5 females, the youngest is 50 years old and the oldest is 75 years old. Inclusion criteria: in line with the "Recommended Diagnostic Criteria for Osteoporosis in China" (Second Draft). No obvious heart, liver, kidney, pulmonary insufficiency, no various endocrine diseases causing secondary osteoporosis, no tumor, diabetes and other serious diseases that interfere with bone metabolism.

[0052] Normal group: select 10 healthy volunteers aged 50-75, 5 males and 5 males.

[0053] There was no significant difference in age and gender between the two groups (P>0.10), which were comparable.

[0054] All research subjects were informed about this study and signed the informed consent.

[0055] 2....

Embodiment 2

[0080] Embodiment 2QPCR experiment verification of genes differentially expressed in patients with osteoporosis and normal people

[0081] 1. Research object:

[0082] Osteoporosis group: randomly select 50 patients with primary osteoporosis admitted to the orthopedics department of the hospital, 25 males and 25 females, the youngest is 50 years old and the oldest is 75 years old. Inclusion criteria: in line with the "Recommended Diagnostic Criteria for Osteoporosis in China" (Second Draft). No obvious heart, liver, kidney, pulmonary insufficiency, no various endocrine diseases causing secondary osteoporosis, no tumor, diabetes and other serious diseases that interfere with bone metabolism.

[0083] Normal group: 46 healthy volunteers aged 50-75 were selected, 23 males and 23 males.

[0084] There was no significant difference in age and gender between the two groups (P>0.10), which were comparable.

[0085] All research subjects were informed about this study and signed th...

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Abstract

The invention discloses a molecular marker which utilizes a PIGK gene to carry out osteoporosis early diagnosis. With the adoption of a method using a gene chip and QPCR (Quantitative Polymerase Chain Reaction), when blood of normal people and blood of osteoporosis patients have remarkable difference, whether tested people have osteoporosis or not can be judged through detecting an expression condition of the PIGK gene in the blood. According to the correlation of the gene chip and the QPCR, the invention develops a kit for diagnosing the osteoporosis; the kit is used for diagnosing the osteoporosis through detecting the expression of the PIGK gene. The diagnosis kit provided by the invention can be used for early diagnosis of diseases and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of molecular diagnosis, and relates to a molecular marker for diagnosing osteoporosis, in particular to the application of the molecular marker-PIGK gene in blood in preparing products for diagnosing osteoporosis. Background technique [0002] Osteoporosis (osteoporosis, OP) is a group of bone diseases caused by a variety of reasons. There is normal calcification in bone tissue, and the ratio of calcium salt to matrix is ​​normal. It is a metabolic bone disease characterized by a decrease in the amount of bone tissue per unit volume. . In most cases of osteoporosis, the loss of bone tissue is mainly due to increased bone resorption. Characterized by bone pain and susceptibility to fractures. [0003] The World Health Organization has listed osteoporosis as the second largest disease that endangers human health after cardiovascular disease. According to the latest "2013 China Osteoporotic Fracture Prevention Blue Bo...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11G01N33/53C40B40/08C40B40/10
CPCC12Q1/686C12Q1/6837C12Q1/6841C12Q1/6869C40B40/08C40B40/10G01N33/53C12Q2561/113C12Q2545/114
Inventor 宋宏涛任静杨承刚
Owner BEIJING MEDINTELL BIOMED CO LTD
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