Breathable degradable dressing and preparation method thereof

A technology of hyaluronic acid and parts by mass, applied in the field of medical materials, can solve the problems of poor air permeability, unfavorable water vapor evaporation, troublesome use, etc., and achieve the effects of short degradation time, good market prospects, and good air permeability.

Inactive Publication Date: 2016-01-13
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During the use of the dressing, especially when the temperature is high, the air permeability is poor, which is not conducive to the evaporation of water vapor and affects the therapeutic effect. At the same time, the dressing is not easy to degrade and is more troublesome to use.

Method used

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  • Breathable degradable dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A breathable and degradable dressing, consisting of the following components by mass: 34 parts of sodium carboxymethylcellulose, 17 parts of hyaluronic acid, 5 parts of calcium alginate, 1 part of β-cyclodextrin, and tributyl citrate 2 parts of ester, 9 parts of polyvinyl alcohol, 3 parts of ethylenediaminetetraacetic acid, 2 parts of nano-zinc oxide, and 1 part of boric acid.

[0017] Preparation:

[0018] (1) Mix sodium carboxymethylcellulose, hyaluronic acid, β-cyclodextrin, nano-zinc oxide, polyvinyl alcohol and calcium alginate according to the above parts by mass, and obtain mixture 1 after ultrasonication for 5 minutes;

[0019] (2) Add tributyl citrate, ethylenediaminetetraacetic acid and boric acid to mixture 1, place in a mixer, and stir evenly at a temperature of 60° C. to obtain mixture 2, wherein the pressure of the mixer is 1.4 MPa;

[0020] (3) Soak the degreasing gauze in the mixture 2, place it in a dryer, dry it at 70° C., seal it, pack it, and steril...

Embodiment 2

[0022] A breathable and degradable dressing, consisting of the following components by mass: 58 parts of sodium carboxymethylcellulose, 31 parts of hyaluronic acid, 19 parts of calcium alginate, 10.5 parts of β-cyclodextrin, and tributyl citrate 9 parts of ester, 20 parts of polyvinyl alcohol, 11 parts of ethylenediaminetetraacetic acid, 12 parts of nano-zinc oxide, and 8 parts of boric acid.

[0023] Preparation:

[0024] (1) Mix sodium carboxymethylcellulose, hyaluronic acid, β-cyclodextrin, nano-zinc oxide, polyvinyl alcohol and calcium alginate according to the above parts by mass, and obtain mixture 1 after ultrasonication for 15 minutes;

[0025] (2) Add tributyl citrate, ethylenediaminetetraacetic acid and boric acid to mixture 1, place in a blender, and stir evenly at a temperature of 110° C. to obtain mixture 2, wherein the pressure of the blender is 2.7 MPa;

[0026] (3) Soak the degreased gauze in the mixture 2, place it in a dryer, dry it at 90° C., seal it, pack ...

Embodiment 3

[0028] A breathable and degradable dressing, consisting of the following components by mass: 36 parts of sodium carboxymethylcellulose, 19 parts of hyaluronic acid, 6 parts of calcium alginate, 2 parts of β-cyclodextrin, tributyl citrate 3 parts of ester, 11 parts of polyvinyl alcohol, 5 parts of ethylenediaminetetraacetic acid, 4 parts of nano-zinc oxide, and 2 parts of boric acid.

[0029] Preparation:

[0030] (1) Mix carboxymethylcellulose sodium, hyaluronic acid, β-cyclodextrin, nano-zinc oxide, polyvinyl alcohol and calcium alginate according to the above mass parts, and obtain mixture 1 after ultrasonication for 6 minutes;

[0031] (2) Add tributyl citrate, ethylenediaminetetraacetic acid and boric acid to mixture 1, place in a blender, and stir evenly at a temperature of 70° C. to obtain mixture 2, wherein the pressure of the blender is 1.8 MPa;

[0032] (3) Soak the degreasing gauze in the mixture 2, place it in a dryer, dry it at 75° C., seal it, pack it, and steril...

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Abstract

The invention discloses breathable degradable dressing and a preparation method thereof. The dressing comprises, by weight, 34-58 parts of sodium carboxymethyl cellulose, 17-31 parts of hyaluronic acid, 5-19 parts of calcium alginate, 1-10.5 parts of beta-cyclodextrin, 2-9 parts of tributyl citrate, 9-20 parts of polyvinyl alcohol, 3-11 parts of ethylenediamine tetraacetic acid, 2-12 parts of nano-zinc oxide, and 1-8 parts of boric acid. The dressing prepared is high in degrading speed, good in breathability and free of allergy and has a promising market prospect.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a breathable and degradable dressing and a preparation method thereof. Background technique [0002] Dressing is an important function of modern wound dressing, because it replaces the important function of damaged skin, and works until wound healing and skin lesion healing. It protects against mechanical factors (e.g. dirt, impact, inflammation, etc.), against pollution and chemical stimuli; against secondary infection; against desiccation and loss of body fluids (electrolyte loss); against heat loss; actively affects the wound healing process through debridement, Create a microenvironment that promotes wound healing. [0003] During the use of the dressing, especially when the temperature is high, the air permeability is poor, which is not conducive to the evaporation of water vapor and affects the therapeutic effect. At the same time, the dressing is not easy to d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/62A61L15/28A61L15/24A61L15/20A61L15/18
Inventor 喻国贞金仲恩欧阳智琨
Owner SUZHOU COSMETIC MATERIALS
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