Application of stervioside in preparation of therapeutic drug and health product for prehypertension

Abstract

The invention discloses an application of stervioside in the preparation of a therapeutic drug and a health product for prehypertension. Through experimental tests of dietary supplement of stevioside to spontaneously hypertensive rats with blood pressure not elevated yet, it is found that stevioside has an effect of delaying elevation of arterial blood pressure for prehypertension. Stevioside can lower JAK2 / STAT3 and SOCS3 expression, improve vascular insulin resistance and delay elevation of blood pressure. It shows that stevioside can improve resistance vessel functions by inhibiting vascular insulin resistance and delay elevation of blood pressure. Thus, stevioside can be used in preparation of a therapeutic drug and a health product for prehypertension, has a good research and application prospect, and provides a new control strategy and experimental evidence for early effective intervention with prehypertension people so as to prevent generation and development of clinical hypertension.

Description

technical field [0001] The invention belongs to the technical field of medicines for preventing and treating hypertension, and in particular relates to the application of stevioside in the preparation of medicines and health care products for treating prehypertension. Background technique [0002] The incidence of hypertension in the adult population in my country is 18.8%, and 1.5 million people die prematurely due to elevated blood pressure every year. At present, there are about 270 million hypertensive patients in my country, and 2 out of every 10 adults suffer from hypertension, but the awareness rate of hypertension is only 42.6%, and less than 10% of people can effectively control blood pressure. Therefore, the prevalence of hypertension Early prevention and timely treatment are very important. In 2003, JNC7 first proposed the concept of "prehypertension", which refers to systolic blood pressure (SBP) of 120-139mmHg and / or diastolic blood pressure (DBP) of 80-89mmHg. ...

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Problems solved by technology

[0005] However, does dietary supplementation with SVS affect blood pressure in prehypertension? Does SVS have some effect on local insulin sensitivity of vascular tissue? Can SVS delay the rise of blood pressure and prevent the development of hypertension by improving insulin resistance in prehypertension? These issues have not yet been reported

And in the process of hypertension with vascular insulin resistance as one of the manifestations and incentives, can SVS still play a vascular protective role by improving insulin sensitivity? Before prehypertension develops into clinical hypertension, can dietary supplementation with SVS delay the development of hypertension through the above mechanism? these questions are unclear

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