Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antibacterial super lubricious medical material and preparation method thereof and antibacterial super lubricious urinary catheter

A technology of antibacterial substances and amino-terminated lubricants, applied in catheters and other directions, can solve the problems that the antibacterial and lubricating coating of urinary catheters are easy to fall off, and the antibacterial and lubricating effects of urinary catheters are not durable, and achieve stable antibacterial and lubricating properties , long-lasting lubricity and antibacterial properties, and the effect of extending the release time

Active Publication Date: 2016-01-06
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to endow the surface of the urinary catheter with anti-infection and lubricating properties, it is necessary to construct an antibacterial layer and a lubricating layer on the surface of the urinary catheter. Lubricant coating, but the antibacterial and lubricating coating of the catheter made in this way is easy to fall off, resulting in the antibacterial and lubricating effect of the catheter not lasting

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The invention provides a preparation method of an antibacterial super-slip medical material, comprising the following steps:

[0040] a), the medical material matrix and the amino-terminated lubricant are reacted in a solvent to obtain an antibacterial super-slip medical material;

[0041] The medical material matrix includes a medical material loaded with antibacterial substances and a polydopamine layer coated on the surface of the medical material loaded with antibacterial substances.

[0042] In the preparation method provided by the present invention, the antibacterial super-slippery medical material can be obtained by directly reacting the medical material matrix and the amino-terminated lubricant in a solvent. The process is specifically as follows:

[0043] a1), immersing the medical material matrix in the mixed liquid of the amino-terminated lubricant and the solvent, and reacting to obtain the antibacterial super-slip medical material.

[0044] In the prepara...

Embodiment 1

[0064] Preparation of Antibacterial Ultraslip Urinary Catheter

[0065] A), immerse the silicone rubber catheter in chloroform solution of 2wt% triclosan for 0.5h, make the catheter swell, and triclosan migrates to the inside of the catheter at the same time, then evaporate the solvent to dryness at room temperature, Obtain triclosan-loaded urinary catheters;

[0066] B), preparation concentration is the Tris-HCl buffer solution of 0.01mol / L (buffer solution is the aqueous solution of trishydroxymethylaminomethane and hydrochloric acid), then dopamine is dissolved in the Tris-HCl buffer solution, preparation concentration is 1.5mg / L mL of dopamine solution, the pH value of the solution is controlled to be 8.5; the triclosan-loaded catheter obtained in the step A) is mixed with the prepared dopamine solution, the reaction temperature is controlled to be 35 ° C, and the stirring reaction is taken out after 25 hours. Cleaning, obtain the urinary catheter that surface is coated w...

Embodiment 2

[0069] Preparation of Antibacterial Ultraslip Urinary Catheter

[0070]A), immerse the silicone rubber catheter in chloroform solution of 2wt% rifampicin for 3h, make the catheter swell, and rifampicin also migrates to the inside of the catheter, and then evaporate the solvent to dryness at room temperature, Obtain a rifampicin-loaded urinary catheter;

[0071] B), preparation concentration is the Tris-HCl buffer solution of 0.01mol / L (buffer solution is the aqueous solution of trishydroxymethylaminomethane and hydrochloric acid), then dopamine is dissolved in the Tris-HCl buffer solution, preparation concentration is 1.5mg / L mL of dopamine solution, the pH of the solution is controlled to be 8.5; the rifampicin-loaded urinary catheter obtained in the step A) is mixed with the prepared dopamine solution, the reaction temperature is controlled to be 35° C., and the reaction is stirred for 25 hours and taken out. Cleaning, obtain the urinary catheter that surface is coated with...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
friction coefficientaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of medical materials and in particular relates to an antibacterial super lubricious medical material and a preparation method thereof and an antibacterial super lubricious urinary catheter. The antibacterial super lubricious medical material provided by the invention is obtained by carrying out a reaction on a medical material matrix and an amino-terminated lubricant in a solvent; and the medical material matrix comprises a medical material loaded with antibacterial substances and a polydopamine layer coating on the surface of the medical material loaded with the antibacterial substances. The antibacterial super lubricious medical material provided by the invention has the advantages that the polydopamine layer coats the surface of the medical material loaded with the antibacterial substance, so that release rate of the antibacterial substances can be effectively reduced, release time of the antibacterial substances is prolonged, and antibacterial durability of the medical material is enhanced; meanwhile, the lubricant on the surface of the antibacterial super lubricious medical material is fixed on the surface of the medical material by virtue of chemical bonds, so that the lubricant hardly falls off, and lubrication durability of the medical material is greatly improved.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to an antibacterial super-slippery medical material, a preparation method thereof, and an antibacterial super-slippery urinary catheter. Background technique [0002] UTIs account for approximately 40% of all hospital-acquired infections, and 80% of UTIs are caused by urinary catheters. Urinary tract infection caused by urinary catheter accounts for about 35% to 50% of nosocomial infections in developed countries, ranking first in nosocomial infections. In the United States, more than 30 million sets of urinary catheters are used every year, of which the infection rate is 10-30%, and more than 5% of the infections result in death. The annual cost for the treatment of urinary catheter-induced urinary tract infections is about 424 million ~$451 million. In addition, clinically, the urinary catheter needs to be in contact with body tissues for a long-term or short-term. E...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/02C08J7/12A61M25/00
Inventor 石恒冲殷敬华李永刚马才栾世方安佰中陈家悦
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com