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Superfine-pore hydrogel bracket and preparation method therefor

A pore water and gel technology, applied in the field of artificial skin, can solve the problems of natural polymer mechanical properties and processing properties that need to be studied and improved, and achieve the effects of good water vapor transmission rate, simple operation and good biocompatibility

Inactive Publication Date: 2015-12-23
南京吾岳道医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the mechanical properties and processing properties of natural polymers need to be studied and improved

Method used

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  • Superfine-pore hydrogel bracket and preparation method therefor
  • Superfine-pore hydrogel bracket and preparation method therefor
  • Superfine-pore hydrogel bracket and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 1g of sodium alginate and dissolve it in 100mL of aqueous solution, add it to a 250mL beaker, seal the mouth of the beaker with wax film, and completely dissolve it to a transparent and clear solution at a speed of 500r / min and a temperature of 28℃ to make 0.01g / mL of sodium alginate solution; weigh 2gCaCl 2 Dissolve in 100mL water solution to prepare 0.02g / mL CaCl 2 Aqueous solution; CaCl 2 The aqueous solution and DMSO are mixed at a volume ratio of 1:1 to form CaCl 2 Mixed solution of aqueous solution and DMSO. Add 3 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, make the sodium alginate solution evenly cover the bottom of the petri dish, let it stand for 10 minutes, and use a disposable dropper to quickly and evenly drop CaCl 2 The mixed solution of the solution and DMSO was 3 mL, and the petri dish was quickly put into a low-pressure vacuum drying box, and dried at -0.1 mPa for 10 minutes, and then a completely cross-linked skin cell s...

Embodiment 2

[0019] Weigh 3g of sodium alginate and dissolve it in 100mL of aqueous solution, add it to a 250mL beaker, seal the mouth of the beaker with wax film, and use a rotation speed of 500r / min and a temperature of 28℃ to completely dissolve it to a clear and clear solution to make 0.03g / mL of sodium alginate solution, weigh 2gCaCl 2 Dissolve in 100mL water solution to prepare 0.02g / mL CaCl 2 Aqueous solution, CaCl 2 The aqueous solution and DMSO are mixed at a volume ratio of 1:1 to form CaCl 2 Mixed solution of aqueous solution and DMSO. Add 3 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, make the sodium alginate solution evenly cover the bottom of the petri dish, let it stand for 10 minutes, and use a disposable dropper to quickly and evenly drop CaCl 2 The mixed solution of the solution and DMSO was 3 mL, and the petri dish was quickly put into a low-pressure vacuum drying box, and dried at -0.1 mPa for 10 minutes, and then a completely cross-linked skin...

Embodiment 3

[0021] Weigh 1g of sodium alginate and dissolve it in 100mL of aqueous solution, add it to a 250mL beaker, seal the mouth of the beaker with wax film, and use a rotation speed of 500r / min and a temperature of 28℃ to completely dissolve to a transparent clear solution to make 0.01g / mL of sodium alginate solution, weigh 2gCaCl 2 Dissolve in 100mL water solution to prepare 0.02g / mL CaCl 2 Aqueous solution, CaCl 2 The aqueous solution and DMSO are mixed at a volume ratio of 2:1 to form CaCl 2 Mixed solution of aqueous solution and DMSO. Add 3 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, make the sodium alginate solution evenly cover the bottom of the petri dish, let it stand for 10 minutes, and use a disposable dropper to quickly and evenly drop CaCl 2 The mixed solution of the solution and DMSO was 3 mL, and the petri dish was quickly put into a low-pressure vacuum drying box, and dried at -0.1 mPa for 10 minutes, and then a completely cross-linked skin ...

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Abstract

The invention relates to a superfine-pore hydrogel bracket and a preparation method therefor. Sodium alginate, calcium chloride, pure water and dimethyl sulfoxide (DMSO) serve as main materials, pores are rapidly formed in a low-temperature and vacuum manner, the process is simple in operation, the materials are easily obtained and are low in cost, and the pore forming method is different from those for preparation of previous numerous bracket materials. The obtained material has superfine pores, meets the requirements of Skin tissue engineering on bracket materials and is good in both strength and toughness.

Description

Technical field [0001] The invention belongs to the technical field of artificial skin, and specifically relates to an ultrafine pore hydrogel scaffold and a preparation method thereof. Background technique [0002] In the study of hydrogel scaffolds, scaffolds are used as extracellular matrix to provide cells with an environment for adhesion, growth, migration, proliferation and differentiation. They play a key role in the construction of hydrogel scaffolds and determine the hydrogel Many properties of the bracket. The invention uses calcium alginate gel as a stent material, and uses dimethyl sulfoxide (DMSO) to make holes through a low-temperature and rapid vacuum method to prepare a degradable hydrogel stent with ultrafine pores. [0003] The existing biomaterials for tissue engineering porous scaffolds mainly include synthetic polymers and natural polymers. Synthetic polymers mainly include polylactide, polyglycolide and polyvinyl alcohol. Synthetic polymers can be produced on...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/60A61L27/56
Inventor 王婷俞倩马靖程帆陈战
Owner 南京吾岳道医疗科技发展有限公司
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