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A kind of nortriterpenoid saponin compound and its preparation method and application

A compound, nortriterpene technology, applied in steroids, organic chemistry, pharmaceutical formulations, etc., to achieve environmental friendliness, low toxicity to humans and animals, and overcome application limitations

Active Publication Date: 2017-08-25
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] North American Salicornia has no pharmacological activity reports, but it belongs to the same relative species and has medicinal value

Method used

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  • A kind of nortriterpenoid saponin compound and its preparation method and application
  • A kind of nortriterpenoid saponin compound and its preparation method and application
  • A kind of nortriterpenoid saponin compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]30Kg of the whole herb of Salicornia chinensis was extracted three times with 90% ethanol under reflux, the dosage was 200 liters, each time for 3 days, concentrated and combined into a concentrated solution without alcohol smell to obtain the total extract. Then sequentially extracted with petroleum ether, ethyl acetate, n-butanol. The n-butanol extract was separated by column chromatography to obtain 3 grams of salicordin. (see attached Figure 8 )

Embodiment 2

[0045] 10Kg of Salicornia whole herb, extracted three times by heating with water, the water consumption is 20 liters, the extraction time is 1 hour, the extraction temperature is 70°C, and the extract is absorbed by macroporous resin (D101, AB-8, HP-20, etc.) , washed with water and 30% ethanol and then eluted with 70% ethanol, and the 70% ethanol eluate was recovered under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.8 g of salicordin.

Embodiment 3

[0047] 10Kg of Salicornia chinensis whole herb was extracted three times by cold immersion in methanol, the amount of methanol used was 20 liters, the extraction time was 1 day, and the extract was adsorbed by macroporous resin (D101, AB-8, HP-20, etc.). After washing with water and 30% ethanol, it was eluted with 70% ethanol, and the 70% ethanol eluate was recovered under reduced pressure to obtain a saponin mixture. The mixture was separated by column chromatography (silica gel column chromatography: chloroform-methanol system, RP-C18 column chromatography: water-methanol system) to obtain 0.9 g of salicordin, respectively.

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Abstract

The invention relates to a nortriterpene saponin compound and its preparation method and use, which belong to the field of natural medicinal chemistry, and are characterized in that it is extracted, separated and purified from the whole plant of Salicornia chinensis through the chemical method of water or organic solvents to obtain A new nortriterpenoid compound named saponin. The compound can inhibit the growth of pathogenic bacteria in vitro, which proves that the saponin din has a new application in the preparation of antifungal and bacterial drugs.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a new saponin extracted and separated from Salicornia saponica, a preparation method thereof, and an application of the saponin in preparing antifungal and bacterial medicines. Background technique [0002] North American samphire, also known as Bigelow's samphire ( Salicornia bigelovii Torr.), belonging to the genus Salicornia in the family Chenopodiaceae ( Salicornia L.) Plants can be irrigated directly with seawater. The cultivation of Salicornia is beneficial to improving the ecological environment, constructing ecological wetlands, and providing food and habitat for wild birds. [0003] At the same time, Salicornia has a variety of comprehensive utilization methods. The oil content of its seeds is about 30%, and the unsaturated fatty acid content is as high as 90%. 40 times that of vegetables, and can be used as raw materials for green organic vegetables, health food, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61K31/704A61P31/04A61P31/10
Inventor 单宇冯煦王奇志管福琴王鸣陈雨印敏赵友谊徐曙
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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