Traditional Chinese medicine combination treating hypertension and application thereof

A composition and high blood pressure technology, which is applied in the direction of drug combination, drug delivery, and medical preparations containing active ingredients, etc., can solve the problems of side effects of antihypertensive western medicines and cannot satisfy patients, and achieve non-toxic side effects, low price, The effect of wide source of raw materials

Inactive Publication Date: 2015-12-16
江志鑫
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are many kinds of antihypertensive drugs for the treatment of hypertension at home and abroad, most of which are western medicines for oral administration, such as compound reserpine, compound antihypertensive tablets and other antihypertensive drugs, which need to be taken for a long time, and most antihypertensive western medicines have side effects. Once the drug is stopped, it rebounds immediately, which cannot meet the needs of patients

Method used

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  • Traditional Chinese medicine combination treating hypertension and application thereof
  • Traditional Chinese medicine combination treating hypertension and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of Chinese medicine extract

[0016] Herbal medicine prescription: tea tree root 2.8kg, plantain 2.5kg, fried tribulus terrestris 1.1kg, lotus leaf 2.1kg, cockscomb flower 1.1kg, hanging golden lamp 1.1kg, Morinda officinalis 1.1kg, cypress kernel 0.9kg, aristolochia 0.9 kg, Toosendan 0.9kg.

[0017] Preparation method: Weigh the above-mentioned Chinese medicinal materials, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add 12 times the amount of water for the first time, decoct Boil for 2 hours, take the decoction, filter, add 10 times the amount of water of the medicinal materials for the second time, decoct for 1.5 hours, combine the two decoctions, filter, and concentrate to a concentrated solution with a relative density of 1.10 at 90°C; The concentrated solution was refrigerated at 3-5°C for 24 hours, added 0.3%...

Embodiment 2

[0018] Embodiment 2: the preparation of Chinese medicine oral liquid

[0019] Herbal medicine prescription: tea tree root 3.0kg, plantain 3.0kg, fried tribulus terrestris 1.2kg, lotus leaf 2.5kg, cockscomb 1.4kg, hanging golden lamp 1.4kg, Morinda officinalis 1.4kg, cypress kernel 1.2kg, aristolochia 1.2 kg, Toosendan 1.2kg.

[0020] Preparation method: Weigh the above-mentioned Chinese medicinal materials, wash and remove impurities, add water to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, and add up to 12 times the medicinal materials for the first time amount of water, decoct for 2 hours, take the decoction, filter, add 10 times the amount of water of the medicinal materials for the second time, decoct for 1.5 hours, take the two decoctions and combine, filter, and when concentrated to 90 ° C, the relative density is The concentrated solution of 1.10; put the c...

Embodiment 3

[0021] The antihypertensive effect of embodiment 3 Chinese medicine extracts on spontaneously hypertensive rats

[0022] Select 40 clean grade spontaneously hypertensive rats (SHR) aged 10 weeks, male, with a body weight of 270-300g, and the SHRs are randomly divided into the following four groups: the control group and the low, medium and high dose groups of the extract. Group 10. After the test started, the control group was administered with normal saline 5ml / kgBW / d; the low, medium and high dose groups of the extract were administered with 150, 300, and 600 mg / kgBW / d of the traditional Chinese medicine extract prepared in Example 1, respectively. After the drug was dissolved in water, the drug was administered by gavage, once a day, for 8 consecutive weeks. The arterial systolic pressure of rats in awake state was measured by tail artery manometry (the tail was heated for 5 minutes). The blood pressure was measured by rat tail manometry every 2 weeks before and after the...

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Abstract

The invention relates to a traditional Chinese medicine combination treating hypertension and application thereof. The combination is prepared from, by weight, 23-35 parts of tea tree roots, 21-30 parts of plantain herb, 8-14 parts of fried caltrop, 17-25 parts of lotus leaves, 8-14 parts of cockscomb, 8-14 parts of lantern plant calyx, 8-14 parts of morinda officinalis, 6-12 parts of platycladi seeds, 6-12 parts of birthwort and 6-12 parts of Szechwan chinaberry fruits. Effective components of traditional Chinese medicine materials are extracted through a water extraction method and are prepared into oral liquid and other oral preparations, and the traditional Chinese medicine combination has the advantages of being little in use amount, stable in blood pressure reduction, little in irritation, free of toxic and side effects, wide in raw material resource, low in price and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating hypertension and its application. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. According to the 2004 survey on nutrition and health status of Chinese residents, the prevalence rate of hypertension among residents aged 18 and over in my country is 18.8%, and it is estimated that the number of patients nationwide exceeds 160 million. Compared with 1991, the prevalence rate increased by 31%, and the number of patients increased by about 70 million people. In 1998, cerebrovascular disease was the second leading cause of death among urban residents in my country and the first in rural areas. There are more than 1 million deaths every year in the country, and about 5 to 6 million surviving patients, of which mor...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K9/20A61K9/48A61K9/14A61K9/08A61P9/12
Inventor 不公告发明人
Owner 江志鑫
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