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Correlation between long non-coding RNA H19 and resistance to platinum-based chemotherapy drugs in cancer

A chemotherapy drug and non-coding technology, applied in the fields of biomedicine and pharmaceuticals, can solve problems such as complex mechanisms, improve prognosis, reduce platinum drug resistance, and increase 5-year survival rate

Active Publication Date: 2018-12-21
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the mechanism by which H19 participates in tumorigenesis and development may be more complex
In addition, so far, the involvement of H19 in ovarian cancer cisplatin resistance and the specific mechanism of action have not been reported.

Method used

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  • Correlation between long non-coding RNA H19 and resistance to platinum-based chemotherapy drugs in cancer
  • Correlation between long non-coding RNA H19 and resistance to platinum-based chemotherapy drugs in cancer
  • Correlation between long non-coding RNA H19 and resistance to platinum-based chemotherapy drugs in cancer

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Embodiment Construction

[0029] Embodiments of the present invention will be described in detail below in conjunction with examples. Those skilled in the art should understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention.

[0030] If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased in the market.

[0031] 1. Establishment and identification of drug-resistant human ovarian cancer cell lines

[0032] 1. Cell lines and their culture conditions

[0033] The human ovarian cancer cell line A2780 was purchased from China Center for Type Culture Collection (Address: Wuhan University Campus, No. 299, Bay...

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Abstract

Provided are uses of an agent capable of reducing and / or inhibiting the expression of long non-coding RNA H19 in cancer cells in the preparation of a medicine for treating or preventing cancers, and in the preparation of a medicine for reducing the resistance of cancers to the platinum-based chemotherapeutic drug. Also provided is a use of an agent capable of detecting the expression of a long non-coding RNA H19 in the preparation of a test kit, the test kit being used for diagnosing the occurrence of cancers or predicting a cancer relapse, and for predicting, detecting or diagnosing the resistance to the platinum-based chemotherapeutic drug of a cancer patient.

Description

technical field [0001] The invention belongs to the fields of biomedicine and pharmacy, and in particular relates to the correlation between long non-coding RNA H19 and cancer platinum chemotherapy drug resistance. Background technique [0002] The mortality rate of ovarian cancer still ranks first in gynecological tumors. Although the treatment of ovarian cancer has been continuously improved, such as the expansion of surgical resection and the combination chemotherapy of paclitaxel and platinum drugs, the mortality rate is still high. It is reported that the five-year survival rate of stage III patients is only 29%. The reason is that in addition to the difficulty of early diagnosis, chemotherapy resistance is an important factor affecting the survival rate of ovarian cancer patients. Currently, platinum-based drugs are one of the first-choice drugs in the chemotherapy regimen for ovarian cancer. Although the effective rate of platinum-based combined chemotherapy for ova...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61K38/46A61P35/00C12Q1/6886C12N15/11
CPCA61K31/7088A61K48/00C12N15/113C12Q1/68
Inventor 华跃进郑智国徐虹
Owner ZHEJIANG UNIV
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