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Application of astaxanthin in preparation of medicine preventing and curing diabetic depression

A technology of diabetes and astaxanthin, which is applied in the field of preparation, prevention and treatment of diabetes and depression of astaxanthin, and can solve unclear problems

Inactive Publication Date: 2015-12-02
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Exactly how dietary habits have these effects, however, remains unclear

Method used

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  • Application of astaxanthin in preparation of medicine preventing and curing diabetic depression
  • Application of astaxanthin in preparation of medicine preventing and curing diabetic depression
  • Application of astaxanthin in preparation of medicine preventing and curing diabetic depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preventive intervention effect of astaxanthin on depression in type 2 diabetes mellitus

[0048] figure 1 The experimental flow chart in Example 1 is realized. Specifically, 20 healthy male SD rats were randomly divided into five experimental groups, namely: A group (normal control group), B group (simple high-fat group), C group (high-fat+STZ group), Group D (high fat + astaxanthin prevention + STZ group), group E (high fat + astaxanthin prevention group), 4 rats in each group. The normal control group was fed with common rat feed for 10 weeks, and the rats in other groups were fed with high-fat feed at the same time. From the 7th week, the rats in group D and E were treated with astaxanthin at a dose of 25 mg / kg. For prevention, at the same time, groups A, B, and C were given the same amount of normal saline, and the time period was 4 weeks. After the prevention, the rats in each group were fasted for 12 hours, and the next day, the rats in group C and D were injec...

Embodiment 2

[0050] Therapeutic effect of astaxanthin on depression in type 2 diabetes mellitus

[0051] This experiment was carried out simultaneously with the above-mentioned preventive effect experiment. Such as the experimental flow chart (see figure 2 ) shows: 20 male healthy SD rats were taken, and 4 were randomly selected as the normal control group, and fed with common rat diet for 6 weeks. Rats in other groups were synchronously fed with high-fat diet for 6 weeks and then intraperitoneally injected with 1% STZ citrate buffer at a dose of 25 mg / kg. Afterwards, the tail was cut and the blood was taken to measure the random blood glucose value. Eight animals with random blood glucose value ≥ 11.1 mol / L were selected as experimental rats, and randomly divided into the diabetes group and the treatment group with 4 rats in each group. The dose of astaxanthin given to the treatment group was 25 mg / kg; the other groups were given the same amount of normal saline at the same time, and e...

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Abstract

The invention discloses application of astaxanthin in the preparation of a pharmaceutical composition recovering a phosphorylated AKT level in diabetic depression prevention and treatment; the invention also discloses the pharmaceutical composition preventing and curing diabetic depression, and the pharmaceutical composition is characterized by containing the astaxanthin.

Description

technical field [0001] The present invention relates to the application of astaxanthin in the preparation of prevention and treatment of diabetic depression, more specifically, the application of astaxanthin in the preparation of a pharmaceutical composition for restoring the level of phosphorylated AKT in the prevention and treatment of diabetic depression. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. Depression is a common disease in psychiatry, which seriously disturbs the life and work of patients and brings serious consequences to society and family. Most patients with depression spend their whole lives in panic, and many patients with depression end their lives early because they cannot bear long-term mental pain and torture. According to literature reports: about 15% of patients with depression die of suicide. It can be seen clinic...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P3/10A61P25/24
Inventor 柯钰婷步世忠张宜生赵明马丽丽
Owner NINGBO UNIV
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