Purpose of nolvadex

A technology of tamoxifen and methyl tamoxifen, applied in the field of biomedicine, can solve the problems of no specific drugs, limited understanding of the pathological mechanism of FXS and autism, etc.

Inactive Publication Date: 2015-11-25
王红兵 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Due to the limited understanding of the pathological mechanism of FXS and autism, there is no specific drug for this disease so far

Method used

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  • Purpose of nolvadex
  • Purpose of nolvadex
  • Purpose of nolvadex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The use of tamoxifen in this example is specifically the application of tamoxifen in the preparation of drugs for the prevention and treatment of autism, fragile X syndrome and related symptoms. The preparation method of the drug is the prior art. I won't repeat them here.

Embodiment 2

[0037] The use of tamoxifen in this example is specifically the application of tamoxifen citrate in the preparation of drugs for the prevention and treatment of autism, fragile X syndrome and related symptoms. The preparation method of the drug is not described here. Let me repeat.

Embodiment 3

[0039] The use of tamoxifen in this example is specifically the application of tamoxifen citrate in the preparation of drugs for the prevention and treatment of autism, fragile X syndrome and related symptoms, and the preparation method of the drug will not be described here repeat.

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Abstract

The invention discloses the purpose of nolvadex and belongs to the technical field of biological medicine. In vitro cell culture tests prove that the nolvadex can inhibit mGluR1 / 5 and Gq-mAChR receptor activity or intracellular signal transduction caused by mGluR1 / 5 and Gq-mAChR receptor activation, reduce or stop the overactivity of the two receptors, and eliminate or weaken the adverse effect caused by the overactivity on cell functional changes. Meanwhile, autism and fragile X syndrome animal model tests prove that the nolvadex can correct hyperactivity behaviors and repeated behaviors, recover passive escape memory ability and contextual fear memory ability and correct the cognition ability defects of autism and fragile X syndrome animal models. The nolvadex can be made into medicine for preventing and treating autism and fragile X syndrome, and the medicine has potential clinical application value.

Description

technical field [0001] The invention specifically relates to a use of tamoxifen, which belongs to the technical field of biomedicine. Background technique [0002] With the increasing difficulty and development cost of new drug development, large pharmaceutical companies around the world are gradually paying attention to the secondary development of drug products, such as expanding new indications of existing drugs, developing new dosage forms, etc., in order to obtain new effective therapeutic drugs. After long-term clinical observation of a large number of cases after listing, the safety of old drugs is guaranteed, the adverse reactions are comprehensively understood, and the chemical or biosynthetic pathways are mature. To develop new indications, the cost of pre-clinical trials can also be relatively saved . Therefore, expanding the use of new indications for old drugs that have been clinically used can greatly promote the development of clinical treatment, save health ...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61P25/00A61P25/28A61P25/14
CPCA61K31/138
Inventor 王红兵任建华李轩
Owner 王红兵
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