Preparation method and application of Shenmei Yangwei granule

A granule and stomach-nourishing technology, which is applied in the field of preparation of Shenmei Yangwei granules, can solve the problems of rough technology, backwardness, and large dosage of patients

Active Publication Date: 2017-10-27
NANJING TONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of resin technology in the extraction and preparation of Shenmei Yangwei Granules, but the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparation method and application of Shenmei Yangwei granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Get 140g of Radix Ginseng, 105g of Safflower, 175g of Dandelion, 175g of Radix Paeoniae Alba, 117g of Hawthorn, 105g of Curcuma, 140g of Salvia Miltiorrhiza, 117g of Angelica, 35g of Black Plum, 70g of Echinacea, 70g of Glycyrrhizae, add 8 times the amount of distilled water to extract two Once, each time for 1.5 hours, combine the extracts, concentrate to 0.4ml / g crude drug, add ethanol to make the alcohol content reach 80%, let it stand for 8 hours, filter with suction, take the supernatant, and pass the drug solution through D1010 macropore adsorption Resin column, washed with water until colorless, eluted with 90% ethanol, collected eluate 10BV, evaporated to dryness to obtain part A; concentrated the washing liquid after passing through the macroporous resin, adjusted the pH value of the liquid to 2, and applied the 732 type Cationic exchange resin, washed with water until colorless, eluted with 40% ethanol containing 3% ammonia water, collected the eluat...

Embodiment 2

[0012] Example 2: Experimental Research Data of Shenmei Yangwei Granules Inhibiting the Proliferation of Human Prostate Cancer Cell DU145 Cells

[0013] 1 Experimental materials

[0014] 1.1 The cell line used in the experiment: human prostate cancer cell DU145 cells, the laboratory cell bank of Nanjing Tongrentang Pharmaceutical Co., Ltd., DMEM+10%FBS conventional culture.

[0015] 1.2 Experimental drug: Research drug: Shenmei Yangwei granule of the present invention: prepared according to the method in Example 1. Medicinal solution stock solution: Weigh 100mg of Shenmei Yangwei Granules, dissolve in 5ml of absolute ethanol, filter through a 0.2μm filter, aliquot into 500μl doff tubes, store at -20°C, and filter absolute ethanol through a 0.2μm filter for the control group for.

[0016] 1.3 Experimental reagents: DMEM (GIBCO Cat.No.12100-061 Lot.No.758137); fetal bovine serum (Zhejiang Tianhang Biotechnology Co., Ltd. Lot.No.100419); NaHCO3 (Shanghai Jiuyi Chemical Reagent ...

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Abstract

The invention belongs to the field of a traditional Chinese medicinal preparation, and in particular provides a preparation method of a Shenmei stomach-nourishing particle (containing ginseng and dark plum). The stomach-nourishing particle is prepared from the following medicinal raw materials: 140g of radix glehniae, 105g of safflower, 175g of dandelion, 175g of radices paeoniae alba, 117g of hawthorn, 105g of curcuma zedoary, 140g of radix salviae miltiorrhizae, 117g of radix angelicae sinensis, 35g of dark plum, 70g of elecampane inla root and 70g of liquorice root by virtue of macroporous resin, cation exchange resin and anion exchange resin, so that content is greatly improved and dosage is reduced. The invention also provides application of the Shenmei stomach-nourishing particle in preparing medicines for inhibiting proliferation of human prostatic cancer cells DU145.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Shenmei Yangwei Granules. Background technique [0002] Shenmei Yangwei Granules are recorded in the Ministry of Health standard, consisting of 140g of North Radix Ginseng, 105g of Safflower, 175g of Dandelion, 175g of White Peony, 117g of Hawthorn, 105g of Curcuma, 140g of Salvia, 117g of Angelica, 35g of Ume, 70g of Echinacea, and 70g of Licorice. Made from raw materials, decocted with water, and made into granules. Nourishing yin and stomach. For burning stomach pain, noisy hunger, dry mouth and throat, dry stool; superficial gastritis, chronic gastritis with insufficient stomach yin and various stomach discomforts. [0003] In the prior art, there is no report on the use of resin technology in the extraction and preparation of Shenmei Yangwei Granules, but the method of decocting in water is rough, ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/16A61P1/14A61P35/00
Inventor 周勤文陈家进
Owner NANJING TONGRENTANG PHARM CO LTD
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