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Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy

A technology of ischemic cerebral apoplexy and tortuol, which is used in drug combinations, cardiovascular system diseases, active ingredients of hydroxyl compounds, etc.

Inactive Publication Date: 2015-11-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, totolol as an antioxidant for the protection of ischemic nerves has not been reported

Method used

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  • Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy
  • Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy
  • Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy

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Embodiment Construction

[0021] After cerebral ischemia occurs, the end of the nerve axon will release a large amount of glutamate after receiving the ischemic signal. Promote Na + , Ca 2+ Influx causes changes in osmotic pressure and electrochemistry of nerve cells, cell edema, calcium overload, and ultimately leads to the breakdown of cytoskeleton and neuron necrosis.

[0022] Table 1 shows the survival rate of cortical neuron cells after glutamate stimulation. The results show that tatopol can reduce the excitotoxicity of cortical neuron cells caused by glutamate.

[0023] Table 1

[0024] Group

[0025] After the occurrence of cerebral ischemia, as the time of hypoglycemia and hypoxia increases, intracellular Ca 2+ Significantly increased, apoptosis and necrosis increased significantly. The hypoglycemia and hypoxia model of cells is a classic model that simulates clinical cerebral ischemia and reperfusion.

[0026] Table 2 shows the survival rate of cortical neuronal cells after hypoglycemia and hypox...

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Abstract

The invention belongs to the field of pharmaceuticals and relates to application of totarol serving as a natural product extracted from podocarpus totara to preparation of a drug for preventing and treating ischemic cerebral apoplexy. A result obtained by researching glutamic acid of rat cortex neurons, a hypoxia and hypoglycemia model and a rat middle cerebral artery occlusion experimental model shows that the totarol can be used for reducing neurotoxicity caused by glutamic acid, reducing neuron injury caused by hypoxia and hypoglycemia, improving the activity of glutathione peroxidase in cortical neurons and brain tissues and the activity of superoxide dismutase, reducing the volume of cerebral ischemia infarct caused after cerebral apoplexy and improving the scores of neurological behaviors. The result proves that the totarol has a remarkable neuroprotective effect for ischemic brain tissues and can be used for preparing a drug for preventing and treating ischemic cerebral apoplexy.

Description

Technical field [0001] The invention belongs to the field of pharmacy, and relates to the application of the natural product totopol extracted from Podocarpus serrata in the preparation of pharmaceutical compositions, in particular to the preparation of drugs for preventing and treating ischemic stroke. Background technique [0002] Ischemic stroke is a kind of cerebral blood circulation disorder with high morbidity, disability and mortality. Studies have shown that excitotoxicity caused by glutamate (Glu) and excessive reactive oxygen species (ROS) are the main causes of damage to the cerebrovascular system. Reduced glutathione (Glutathione, GSH), superoxide dismutase (superoxide dismutase, SOD), etc. are the endogenous antioxidant system of brain tissue, which has an antioxidant effect. [0003] Taotopol is a natural product extracted from the heartwood of Taotuo Podocarpus. Research reports have proved that Taotopol has anti-plasmodium, anti-microbial and anti-fungal effects. ...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P9/10
Inventor 李萍张陆勇庞涛徐晓军高原雪
Owner CHINA PHARM UNIV
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