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Tracheal stent and application thereof

A tracheal stent and trachea technology, applied in the field of medical devices, can solve the problems of destroying the three-layer structure of the trachea, granulation proliferation, air leakage, etc., and achieve the effects of good mechanical properties, appropriate types, and avoiding air leakage.

Inactive Publication Date: 2015-11-18
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both end-to-end anastomosis and slide anastomosis have destroyed the three-layer structure of the trachea, especially the mucosal epithelial layer and submucosal connective tissue layer, resulting in postoperative complications such as air leakage, bleeding, and granulation hyperplasia.
So, can the tracheal stenosis be repaired without destroying the tracheal epithelial layer and submucosal connective tissue layer, so as to avoid the defects of traditional surgical methods? There is no report about this kind of operation method and surgical instrument at present

Method used

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  • Tracheal stent and application thereof
  • Tracheal stent and application thereof
  • Tracheal stent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 Tracheal stent of the present invention

[0047] See figure 2 , figure 2 It is a structural schematic diagram of the tracheal stent of the present invention. The trachea stent is provided with a support ring 1 and a support link 2 . There are several support rings 1, and each support ring 1 has the same shape and size, which is C-shaped. The supporting links 2 are respectively connected in series, so that each supporting ring 1 and the supporting link 2 are fixed together to form a hollowed-out circular tubular structure with an axial notch 3 on the side wall.

[0048] The specifications of the tracheal stent of the present invention are preferably: the inner diameter is 5-10 mm, the outer diameter is 6-12 mm, the width of the support ring 1 is 1-3 mm, and the gap between adjacent support rings 1 is 1-4 mm. Most preferably, the inner diameter is 7 mm, the outer diameter is 8 mm, the thickness of the support ring 1 is 1 mm, the width of the support rin...

Embodiment 2

[0052] Embodiment 2 Tissue engineered trachea of ​​the present invention

[0053] See image 3 , image 3 It is a schematic diagram of the tissue engineered trachea structure of the present invention. The tissue engineered trachea is provided with a tracheal stent 10 and a cell-electrospun membrane composite 20 . The tracheal stent 10 is as described in Embodiment 1. The cell-electrospun membrane complex 20 is gelatin / polycaprolactone electrospun membrane inoculated with chondrocyte suspension. The cell-electrospun membrane composite 20 is covered on the outer surface of the tracheal stent 10, and the axial ends are curled toward the inside of the tracheal stent 10 at the position of the axial notch 3 of the tracheal stent 10, and coated on the tracheal stent 10 on the inner wall.

[0054] The schematic diagram of tissue engineering trachea construction of the present invention can be found in Figure 4 .

Embodiment 3

[0055] Embodiment 3 Construction of tissue engineering trachea of ​​the present invention (1)

[0056] 1. Method

[0057] 1.1 In vitro construction of tissue engineered trachea

[0058] The preparation of gelatin / polycaprolactone electrospun membrane: take by weighing 0.5g gelatin and 0.5g polycaprolactone with electronic analytical balance and be dissolved in the trifluoroethanol of 10ml, stir 24h to dissolve completely, obtain concentration is 10% (gram / ml) of gelatin / polycaprolactone spinning solution, add 10 μl of acetic acid to the solution, and stir for 10-20min until the solution changes from cloudy to clear. Select a 10ml syringe and a needle with an inner diameter of 1.2mm to extract the gelatin / polycaprolactone spinning solution, fix it on the electrospinning device, adjust the electrostatic voltage to 10kv, the acceptance distance to 12cm, and the injection rate to 2ml / h. Spinning, using aluminum foil as a receiving device, spinning for 3 hours to obtain a gelati...

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Abstract

The invention relates to a tracheal stent and application thereof. The tracheal stent comprises supporting rings and a supporting connecting rod, wherein the various supporting rings are of C-shaped structures and are serially connected by virtue of the supporting connecting rod, so that the various supporting rings are integrally fixed with the supporting connecting rod. The invention further provides a tissue engineering trachea, and the tissue engineering trachea is prepared by winding a chondrocyte-gelatin / polycaprolactone electrospun membrane complex on the outer surface of the tracheal stent. The tracheal stent or the tissue engineering trachea disclosed by the invention can be used for repairing tracheal stenosis by virtue of a tracheal external support suspension method, and a new C-shaped cartilaginous ring is formed after the implantation of the tracheal stent or the tissue engineering trachea, so as to guarantee growth potential finally.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a tracheal stent, a tissue engineered trachea based on the tracheal stent, and applications thereof. Background technique [0002] Clinically, the incidence rate of tracheal malformation in children with congenital heart disease (CHD) is relatively high, and literature reports can account for about 12.9% of children with CHD. In my country, the incidence of congenital heart disease is about 0.7% to 0.8%, and about 150,000 new children are born every year. In our Heart Center of Children's Medical Center affiliated to Shanghai Jiaotong University, many children with congenital heart disease are complicated with tracheal malformations every year. Tracheal stenosis is the most common type of malformation of the trachea, and one of the causes is compression and softening of the trachea due to cardiovascular malformations. The treatment of tracheal stenosis in infants and yo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61F2/04
Inventor 付炜殷猛寒露葛阳冯蓓白洁王伟张海波徐志伟
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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