Diagnosis marker suitable for esophagus cancer early-stage diagnosis

Abstract

The invention discloses a diagnosis marker suitable for an esophagus cancer early-stage diagnosis. The diagnosis marker is a combination of two or more than two kinds of materials from the following seven kinds of serum metabolic markers including LPA (lysophosphatidic acid) [18 to 1(9Z) / 0 to 0], LysoPC (lysolecithin) (14 to 0 / 0 to 0), LysoPC (lysolecithin) [18 to 2(9Z,12Z)], LysoPC (lysolecithin) (24 to 0), phospholipids PC [14 to 1(9Z) / P-18 to 1(11Z)], phospholipids PC [16 to 0 / 18 to 2(9Z,12Z)] and phospholipids PC [24 to 1(15Z) / 22 to 6(4Z,7Z,10Z,13Z,16Z,19Z)]. When the diagnosis marker provided by the invention is adopted, a diagnosis model can be built. The diagnosis model has the advantages of good effect, high sensitivity and good specificity, is suitable for late-stage and early-stage esophagus cancer diagnoses, and has good clinic use and popularization value.

Description

technical field [0001] The present invention relates to the diagnosis of esophageal cancer, in particular to a diagnostic marker for esophageal cancer, a screening method for the diagnostic marker, a diagnostic model constructed on the basis of the diagnostic marker, and a method for constructing the diagnostic model, the diagnostic marker and the diagnosis method. The model has good diagnostic effect on esophageal carcinoma in situ, early and advanced esophageal cancer, is particularly suitable for early diagnosis of esophageal cancer, and belongs to the technical field of esophageal cancer diagnosis. Background technique [0002] Esophageal cancer is a malignant lesion formed by abnormal proliferation of esophageal squamous epithelium or glandular epithelium. According to the latest data from the World Health Organization, about 400,000 people die from esophageal cancer every year in the world. my country is the country with the highest incidence and mortality rate of esop...

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Problems solved by technology

[0007] For the diagnosis of esophageal cancer (also known as esophageal squamous cell carcinoma) in the prior art is complicated, expensive, and invasive, the current markers are only highly sensitive to advanced esophageal cancer, and cannot achieve early diagnosis of esophageal cancer, etc. Insufficient, the present invention provides a kind of diagnostic marker that is suitable for the early diagnosis of esophageal cancer, and this diagnostic marker has better sensitivity and specificity for esophageal carcinoma in situ, early esophageal cancer, advanced esophageal cancer, can not only be used for The diagnosis of advanced esophageal cancer can also be better used for early diagnosis of esophageal cancer, which is of great significance for improving the prognosis and reducing mortality of esophageal cancer

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