Integrated micro-fluidic chip for screening drug compatibility, as well as preparation method and application of integrated micro-fluidic chip
A microfluidic chip and drug technology, applied in biochemical equipment and methods, chemical instruments and methods, laboratory containers, etc., can solve the complicated operation, the inability of large-scale application of microfluidic chips, and the complexity of processing and manufacturing and other problems to achieve the effect of simplifying the experimental steps, saving time and convenient operation
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[0040] The present invention will be further described in detail below in conjunction with specific examples.
[0041] see figure 1 , figure 2 , the present embodiment provides an integrated microfluidic chip for drug compatibility screening, including: a fluid channel layer 1, a microvalve control channel layer 2 and a glass substrate layer 3; the fluid channel layer 1 and the microvalve control channel The layer 2 constitutes a fluid channel unit 4 through thermal bonding of PDMS, and the fluid channel unit 4 is integrated with the glass substrate layer 3 through plasma bonding.
[0042] The fluid channel unit 4 includes two functional areas, namely: a drug mixing area 6 and an arrayed cell culture area 7 .
[0043] The drug mixing generation area 6 is used for injection, mixing and generation of the drug to be tested, including: a mixing chamber 8, a connecting channel 9 communicating with the mixing chamber 8, a drug solution injection channel 10 communicating with the ...
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