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Extraction method for plant composition containing silybum marianum and application of plant composition

An extraction method and technology of milk thistle, which are applied in the field of extraction of plant compositions of milk thistle, can solve the problems of large dosage for patients, rough process, influence on clinical application, etc., and achieve the effect of reducing dosage

Inactive Publication Date: 2015-11-11
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing milk thistle. However, the method of decocting in water is rough and backward, with many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • Extraction method for plant composition containing silybum marianum and application of plant composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 100 parts of milk thistle, 50 parts of bamboo ginseng, 60 parts of auspicious grass, 40 parts of Dinggui grass, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract was obtained, and conventional excipients were added to prepare tablets, each tablet 0.4g.

Embodiment 2

[0016] Take 100 parts of milk thistle, 50 parts of bamboo ginseng, 60 parts of auspicious grass, 40 parts of Dinggui grass, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract is obtained, and conventional auxiliary materials are added to prepare capsules.

Embodiment 3

[0018] Take 100 parts of milk thistle, 50 parts of bamboo ginseng, 60 parts of auspicious grass, 40 parts of Dinggui grass, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400-600W, and the extraction time is 2 4-8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, The microwave extract is obtained, and conventional auxiliary materials are added to prepare granules.

[0019] Bamboo ginseng is the dry rhizome of Araliaceae plant Panaxjaponicus C.A.Mey. Excavated in autumn, removed the main root and outer bark, and dried. Nourishing and strong, dissipating blood stasis and relieving pain, stopping bleeding and eliminating phlegm. It is used for weakness after illness, hemoptysis due to labor cough, cough with prof...

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Abstract

The invention provides an extraction method for a plant composition containing silybum marianum. The plant composition is prepared from 100 parts of silybum marianum, 50 parts of panax japonicus, 60 parts of pink reineckea herbs and 40 parts of zornia gibbosa through a microwave extraction method. The content is greatly increased, and the use amount is reduced. The invention further provides an application of the plant composition containing silybum marianum in preparing medicine for restraining mouse lymphoid tumor P388D1 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction method and application of a plant composition containing milk thistle. Background technique [0002] The plant composition containing milk thistle is made from 100 parts of milk thistle, 50 parts of bamboo ginseng, 60 parts of auspicious grass, and 40 parts of Dingguicao as raw materials. The current extraction method is to add water and decoct twice, each time 2 -3 hours, combine the decoction, filter, concentrate into a thick paste, granulate, dry, and coat with sugar. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing milk thistle. However, the method of decocting in water is rough and backward, with many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P35/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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